International Journal of Drug Delivery Technology
Volume 15, Issue 1

Atalantia Racemosa Wight Mitigates Arthritis Through the Modulation of Crucial Immune Mediators of Inflammation in an Experimental Arthritis Model

Pournima Anil Shelar*, Prashant Kumar Dhakad, Ritu Gilhotra

Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India. 

Received: 12th Jan, 2025; Revised: 17th Feb, 2025; Accepted: 4th Mar, 2025; Available Online: 25th Mar, 2025 

ABSTRACT

Objective

The persistent need to discover plant species with anti-arthritic properties prompted the investigation of A. racemosa Wight. The objective is to study anti-arthritic attributes of ethanolic extracts made from A. racemosa leaves and stems.

Methods

Using in vivo model, the anti-arthritic property was evaluated. Acute toxicity was performed as per OECD strategies to determine dose.  Formaldehydeinduced model was used to investigate anti-arthritic action. 200 mg/kg of ethanolic extracts of leaves and stems were given orally. To know the antiarthritic potential of A. racemosa radiology as well as histopathology was performed.

Results

The stem ethanolic extract demonstrated significant reduction in arthritis by showing 49.65% inhibition than leaf ethanolic extract which shows 38.89% inhibition. Chemical examination of the plant's ethanolic leaf and stem extracts shown existence of flavonoids, terpenoids, and steroids. Antiarthritic activity of A. racemosa is supported by histopathology, radiology and haematological analysis.

Conclusion

This study indicates that A. racemosa may be useful as a bioactive chemical source for the treatment of inflammatory disorders and orthopedic pain.

Key Word: Stems, Leaves, Anti-arthritic activity, Histopathology, Radiology. Top of Form

How to cite this article: Pournima Anil Shelar, Prashant Kumar Dhakad, Ritu Gilhotra. Atalantia Racemosa Wight Mitigates Arthritis Through the Modulation of Crucial Immune Mediators of Inflammation in an Experimental Arthritis Model. International Journal of Drug Delivery Technology, 2025;15(1):91-98. doi: 10.25258/ijddt.15.1.12

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