International Journal of Drug Delivery Technology
Volume 15, Issue 1

QbD-Driven Development and Evaluation of EGCG-Loaded Transfersomal Gel for Non-Melanoma Skin Carcinoma 

Singh B , Nanda S* 

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana-124001, India 

Received: 28t Aug, 2024; Revised: 30th Nov, 2024; Accepted: 21st Dec, 2024; Available Online: 25th Mar, 2025 

ABSTRACT

The most common type of cancer is non-melanoma skin cancer (NMSC), necessitating the development of non-invasive and novel method of treatment. The current research study is focused on the design, development, and evaluation of a transfersomal gel loaded with epigallocatechin-3-gallate (EGCG), a bioactive compound with significant anti-cancer properties. After establishing anticancer properties of EGCG using cell lines and in silico studies, transfersomes were formulated using Box-Behnken Design (BBD). Optimization was done with three factors and three levels The optimized transfersomal gel exhibited significant physicochemical characteristics. Smaller V.S., improved Z.P. and high EE facilitated enhanced skin penetration as proved by in vitro and ex vivo studies using porcine skin. These findings demonstrated the potential of transfersomal formulation in enhancing the transdermal delivery of EGCG, paving the way for effective approaches for managing non-melanoma skin cancer. Further, clinical studies can enhance the potential and application of this bioactive molecule.

Keywords: Epigallocatechin-3-gallate (EGCG); skin permeation; transfersome, QbD, Non-melanoma skin cancer; Ex-vivo studies; A431 Cell lines.

How to cite this article: Singh B, Nanda S. QbD-Driven Development and Evaluation of EGCG-Loaded Transfersomal Gel for Non-Melanoma Skin Carcinoma. International Journal of Drug Delivery Technology. 2025;15(1):112-18. doi: 10.25258/ijddt.15.1.15

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