International Journal of Drug Delivery Technology
Volume 15, Issue 1

Formulation and Development of Bilayer floating Tablet of Selective Drugs as GRDDS

Sreedhar Ranjan Das1*, Bibhuti Bhusan Panigrahi2, Manoj Kumar Pani3 

1Sontoshi institute of Pharmaceutical sciences, Manguli, Cuttack., Odisha, India

2Professor and Principal, Einstein College of Pharmacy, Bajapur, Khorda, Bhubaneswar, India

3Indira Gandhi Institute of Pharmaceutical Sciences, Bhubaneswar, India 

Received: 20th Dec, 2024; Revised: 29th Jan 2025; Accepted: 14th Feb, 2025; Available Online: 25th Mar, 2025 

ABSTRACT

The research work based on Bilayer floating tablet of selected  drug  as Sucralfate and Metoprolol succinate.. Sucralfate Immediate release layer containing Sucralfate 100 mg and total weight with excipients is 300 mg . Metoprolol succinate sustained layer containing   Metoprolol succinate 50 mg and total weight with excipients is 200 mg is done. Metoprolol succinate layer (MSF10) the (DSFMS-500mg) produce Average Weight 501.7±0.26 (mg), Thickness 5.99±0.111 mm, Hardness 5.6±0.124KP, Friability 0.543%, FLT 22sec, TFT 18 hrs, Drug Content of Sucralfate 100.02%, Drug Content of Metoprolol Succinate is 99.98%. The TFT. is under acceptance criteria.(18-20hour). So the formulation is the best formulation as GRDDS.

Keywords: Ulcer protective,  Sucralfate, Antihypertensive, Metoprolol Succinate, Bilayer floating tablet

How to cite this article: Sreedhar Ranjan Das, Bibhuti  Bhusan Panigrahi , Manoj Kumar Pani. Formulation and development of Bilayer floating tablet of selective drugs as GRDDS. International Journal of Drug Delivery Technology. 2025;15(1):191-95. doi: 10.25258/ijddt.15.1.27

REFERENCESReferences

  1. Yadav S, Tiwari A. 2012. Areview work done on Floating Drug Delivery System Containing cardiovascular Drugs. IRJP 3(3):97-101.
  2. Subrahmanyam CVS. 2010. Dosage form evaluation–bioavailability. Text Book of Biopharmaceutics and Pharmacokinetics Concept and applications. Ballabh Prakashan.,134-178:1stEdition.
  3. Sharma V, Singh L, Sharma VA. 2011. Novel Approach to Combat Regional Variability. Floating Drug Delivery System .IJPS Review & Research., 8(2):154-159.
  4. Presentationon gastro retentive. 2015. Available at: https://www.slideshare.net/NadiaJawaid/presentation-grdds.AccessedFeb17. Drug Delivery System.
  5. Fatema K, Shaikh T, Zaheer Z. 2016. Gastro retentive drug delivery system: An overview. Asian Pac. Journal of Health Sciences 3(4):131-144.
  6. Sharma AR, Khan A. Gastro retentive drug delivery system: An approach to enhance gastric retention for prolonged drug release. IJPSR; 5 4:1095-1106.
  7. Chawra HS, Tanwar YS, Gilhotra RM, Singh SK. 2018. Gastro retentive drug delivery system: A potential approach for antihypertensive drugs: An updated review. Asian Pacific Journal of Health Sciences 5(2):217-223.
  8. Badoni A, Ojha A, Gnana Ranjan G, Kothiya P. 2012. Review on Gastro retentive drug delivery system: ThePharmaInnovation., 1 8:32-42.
  9. Gholap S, Saluki R, Hemant Kumar J, Kapileswar S. 2016. Reviewon Bilayer floating tablet. WJPPR 5(2):1411-1423.
  10. Lende LK, Banerjee SK. Gan have MV, Gaikwad D. D, Gaydar AJ. 2013. Review on: Bilayer floating tablet. AJPRD.1(1) 31-39.
  11. LaForce C, Gentile DA, Skoner DP. 2008. A randomized, double-blind, parallel group, multicentre,placebo-controlled study of the safety and efficacy of extended-release guaifenesin/ pseudoephedrine hydrochloride for symptom relief as an adjunctive therapy to antibiotic treatment of acute respiratory infections. Postgraduate Medicine 120(2):53-59.
  12. Maggi L, Segal L, Conti S, Ochoa Machete E, Conte U. 2005. Preparation and evaluation of release characteristics of 3TabGum, a novel chewing device. European Journal of Pharmaceutical Sciences 4:487-493.
  13. Park CR, Munday DL. 2002. Formulation and evaluation of biphasic buccal adhesive tablet. International Journal of Pharmacy 237:215-226.
  14. Kulkarni A, Bhatia M. 2009. Development and evaluation of bilayer floating tablets of atenolol and lovastatin for biphasic release profile. Iranian Journal of Pharmaceutical Research 8(1):15-25.
  15. Panchel HA, Tiwari AK. 2012. A Novel approach of bilayer tablet technology- A review.; 3 5:44-49.
  16. Nirmal J, Saisivam S, Peddanna C, Muralidharan S, Godwinkumar S, Nagarajan M. 2008. Bilayer tablets of atorvastatin calcium and nicotinic acid: Formulation and evaluation. Chemical and Pharmaceutical Bulletin 56(10):1455-1458.
  17. Abdul S, Poddar S. 2004. A flexible technology for modified release of drugs: Multi layered tablets. Journal of Controlled Release 97(3):393-405.