International Journal of Drug Delivery Technology
Volume 15, Issue 1

Evaluation of Hepatoprotective Potential of Lamiaceae Family Plants in Rat Models of Alcohol, Paracetamol and Ranitidine-Induced Hepatotoxicity

Subba Rao Chamakuri1,2, Ashish Suttee1*, Prasenjit Mondal3, Dasari Priyanka4 

1Department of Pharmaceutical Sciences, Lovely Professional University, Punjab, Jalandhar – 144 411, India.

2Department of Pharmacognosy, JNTUH, Vaageswari College of Pharmacy, Karimnagar-505 527, Telangana, India.

3Department of Pharmaceutical Technology, Brainware University, Barasat, West Bengal, Kolkata-700 125, India.

4Department of Pharmacology, JNTUH, Vaageswari College of Pharmacy, Karimnagar-505 527, Telangana, India

Received: 10th Oct, 2024; Revised: 21st Nov, 2024; Accepted: 2nd Jan, 2025; Available Online: 25th Mar, 2025 

ABSTRACT

The whole plant of Leucas zeylanica (Lamiaceae) was tested for hepatoprotection in Wistar rats after paracetamol (PCM), ethyl alcohol (ALC), and ranitidine (RTD) produced hepato the albino mouse acute toxicity maximum dosage was 2000 mg/kg. Six animal groups were utilized in all models. Modelling followed Silymarin. MELZWP contains saponins, carbohydrates, flavonoids, tannins, and phenolic from Leucas zeylanica whole plant. LD50 experiments showed these extracts did not kill or alter mice at 2000 mg/Kg body weight. Silymarin and MELZWP dosages increased thiopental sleeping time, wet liver weight, and volume than PCM, ALC, and RTD-induced hepatotoxic mice. Albumin (ALB) and protein (PRO) increased whereas ALT, ALP, AST, CHO, BILT, and TG dropped. Steatosis, necrosis, and other histological abnormalities were disallowed. Saponins and flavonoids protect the liver, study finds.

Keywords: L. zeylanica, hepatoprotective, ranitidine, paracetamol, ethyl alcohol.

How to cite this article: Subba Rao Chamakuri, Ashish Suttee, Prasenjit Mondal, Dasari Priyanka. Evaluation of Hepatoprotective Potential of Lamiaceae Family Plants in Rat Models of Alcohol, Paracetamol, and Ranitidine-Induced Hepatotoxicity . International Journal of Drug Delivery Technology. 2025;15(1):18-26. doi: 10.25258/ijddt.15.1.3

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