International Journal of Drug Delivery Technology
Volume 15, Issue 1

Enhancing Topical Anti-Inflammatory Activity with Psidium guajava L. and Moringa oleifera 

 Udugade Swati B1*, Kadam Aditya D1, Ingale Umakant S2, Udugade Babaso V2, Gandhi Jotsna M1 

1Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University),Karad, Satara, Maharashtra, 415539, India

2Ashokrao Mane College of Pharmacy, Pethvadgoan, Kolhapur, Maharashtra, 416112, India

Received: 9th Jan, 2025; Revised: 4th Feb, 2025; Accepted: 2nd Mar, 2025; Available Online: 25th Mar, 2025

ABSTRACT

The main goal of this research was to formulate and assess herbal topical cream incorporating Psidium guajava and Moringa oleifera extracts to explore their antimicrobial, anti-inflammatory, moisturizing, and skin-protective properties. Three cream formulations (F1, F2, and F3) were prepared by varying the concentrations of the plant extracts while keeping other ingredients constant. The formulations were created through emulsification, where the oil phase (stearic acid, emulsifying wax, propylene glycol, and propyl paraben) and aqueous phase (plant extracts, glycerin, cetyl alcohol, and sodium stearate) were combined at 70°C before cooling and adding perfume.

The prepared formulations were assessed for the parameters such as pH, physical stability, spreadability, viscosity, stability testing, antimicrobial activity, anti-inflammatory efficacy and skin irritation potential. All formulations demonstrated physical stability, with F2 providing an optimal balance of spreadability, viscosity. Antimicrobial activity increased with higher extract concentrations, with F3 exhibiting the largest inhibition zones against bacterial strains. The anti-inflammatory activity, assessed by protein denaturation inhibition and heat-induced hemolysis assays, showed a dose-dependent trend. F3 exhibited the highest inhibition rates (74.5% for protein denaturation and 68.9% for heat-induced hemolysis), followed by F2 and F1.

The study confirmed that incorporating Psidium guajava and Moringa oleifera extracts in cream formulations enhances their antimicrobial and anti-inflammatory properties, providing both cosmetic and therapeutic benefits. These findings support further optimization and clinical exploration for skincare applications.

Keywords: Cream Formulation, anti-inflammatory Activity, Synergistic action and phytochemicals

How to cite this article: Udugade Swati B, Kadam Aditya D, Ingale Umakant S, Udugade Babaso V, Gandhi Jotsna M. Enhancing Topical Anti-Inflammatory Activity with Psidium guajava L. and Moringa oleifera. International Journal of Drug Delivery Technology. 2025;15(1):279-84. doi: 10.25258/ijddt.15.1.39

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