International Journal of Drug Delivery Technology
Volume 15, Issue 1

Evaluation of Metronidazole and Povidone Iodine Coated Vs Non-Coated Sutures Against Specific Periodontal Pathogens: A Comparative Analysis

Kuralvaani M1, Devi Arul1*, Nizar Ahmed2, Supraja A1, Balaji S K1 

1Sri Ramachandra Dental College and Hospital, Chennai- 600116, India

2Sri Venkateshwara Medical College Hospital and Research Institute, Nallur near Redhills Toll Plaza, Chennai 600 067, India

Received: 20th Nov, 2024; Revised: 23rd Dec, 2024; Accepted: 22nd Jan, 2025; Available Online: 25th Mar, 2025

ABSTRACT

Sutures are essential after surgery as they allow for tissue re-approximation, stimulate early healing, and regulate bleeding. To avoid postoperative suture related complications like surgical site infection due to wicking effect, various antimicrobial agents have been incorporated into sutures. In this study, black silk suture was scoured for impurities and coated with metronidazole and povidone-iodine for comparison with the uncoated suture. Blood agar plates were prepared and inoculated with putative periodontal pathogens. The three groups of sutures were studied for their action against specific microbe by measuring the zone of inhibition. Based on the statistical analysis, it is established that povidone iodine and metronidazole coated suture have higher antimicrobial efficacy when compared to non-coated suture against anaerobic periodontal pathogens.

Keywords: Sutures, Metronidazole hydrochloride, Povidone iodine, , Drug delivery system, Gram negative bacteria

How to cite this article: Kuralvaani M, Devi Arul,  Nizar Ahmed, Supraja A, Balaji S K. Evaluation of Metronidazole and Povidone Iodine Coated Vs Non-Coated Sutures Against Specific Periodontal Pathogens: A Comparative Analysis. International Journal of Drug Delivery Technology. 2025;15(1):45-49. doi: 10.25258/ijddt.15.1.6

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