International Journal of Drug Delivery Technology
Volume 15, Issue 2

Studies on Spectral Characterization, Dissolution and Solubility of Aceclofenac Multicomponent Inclusion Complex using Different Auxiliary Agent

Patil P A*, Kumbhar S T 

School of Pharmaceutical Sciences, Sanjay Ghodawat University, Atigre, Kolhapur: 416118, Maharashtra, India

Received: 12th Feb, 2025; Revised: 16th Mar, 2025; Accepted: 24th Apr, 2025 ; Available Online: 25th Jun, 2025 

ABSTRACT

Current research was designed to examine how aceclofenac interacted with cyclodextrin and its derivatives. The different auxiliary agents such as mannitol, L-arginine and citric acid were also evaluated for enhancement solubility of aceclofenac and selected as third component for preparing multicomponent inclusion complex. In direction to increase bioavailability and solubility of the poorly soluble medication aceclofenac, a complex was created that belongs to BCS CLASS-II. The multicomponent inclusion complex was created by using physical mixing and kneading techniques. The distinct concentrations of L-arginine were tested for the ternary systems. Interactions between the solid and liquid phases were studied using FTIR, DSC, XRD, and 1H-NMR. A study on phase solubility proved that L-arginine significantly affected the methyl-β-cyclodextrin complexation with aceclofenac. Saturation solubility study and in-vitro study state that prepared complex shows expansion of solubility similarly bioavailability of poorly water-soluble aceclofenac.

Keywords:  Aceclofenac, methyl-β-cyclodextrin, multicomponent inclusion complex, auxiliary agent, L-arginine.

How to cite this article: Priya A Patil, Subhash T Kumbhar. Studies on Spectral Characterization, Dissolution and Solubility of Aceclofenc Multicomponent Inclusion Complex using Different Auxiliary Agent. International Journal of Drug Delivery Technology. 2025;15(2):494-502. doi: 10.25258/ijddt.15.2.17

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