International Journal of Drug Delivery Technology
Volume 15, Issue 2

Experimental Design for the Formulation and Optimization of Phloroglucinol Mouth Dissolving Tablets

Lammari Narimane*, Mimoune Nada Yasmine, Ouaret Amel

Environmental Process Engineering Laboratory, University Constantine 3, Salah Boubnider, 25000 Constantine, Algeria 

Received: 14th Feb, 2025; Revised: 24th Apr, 2025; Accepted: 15th May, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

The purpose of the present study was to prepare and evaluate Phlorogluinol mouth dissolving tablets using experimental mixture design. Ten different formulations were generated based on three types of disintegrants (croscarmellose sodium, crospovidone and microcrystalline cellulose) by using simplex lattice design with Minitab 1.6® software. Tablets were prepared by direct compression technique. The percentage of drug release at 5min, 30 min and the disintegration time were statistically analyzed to get the optimized formulation.  Drug content, hardness, friability and mass uniformity were carried out on the optimum formulation as further experiments. Tablets containing the mixture of the three disintegrants provided the best release profile and the fast disintegration. The results of the quality control tests for the optimized formulation complied with the requirements of the European Pharmacopoeia 9.2.

Keywords: Phlorogluinol, mouth dissolving tablets, experimental mixture design, disintegrant

How to cite this article: Lammari Narimane, Mimoune Nada Yasmine, Ouaret Amel. Experimental Design for the Formulation and Optimization of Phloroglucinol Mouth Dissolving Tablets. International Journal of Drug Delivery Technology. 2025;15(2): 385-90. doi:10.25258/ijddt.15.2.2

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