International Journal of Drug Delivery Technology
Volume 15, Issue 2

Formulation, Optimization and Characterization of Ticagrelor Loaded NLCs Formulation 

Ahire Sujeetkumar Ishwarlal1*, Gupta Revathi A2 

1Ph.D Cell, Dr. A. P. J. Abdul Kalam University, Indore, India

2Institute of Pharmacy (IOP), Dr. A. P. J. Abdul Kalam University, Indore, India 

Received: 21st Mar, 2025; Revised: 11th May, 2025; Accepted: 22nd May, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

Ticagrelor is a P2Y12 inhibitor for cardiovascular issues and it works by preventing platelet aggregation, thus reducing the risk of thrombotic events. ticagrelor has shown potential benefits in rheumatoid arthritis when combined with methotrexate. Ticagrelor's role in reducing cardiovascular events may be beneficial for patients with rheumatoid arthritis who are at increased risk for cardiovascular issues. The present study was aimed to formulate, optimize and evaluated ticagrelol loaded NLCs using Box-Behnken design was used. The design was implemented to statistically optimise the factors that were independent: drug: lipid ratio (X1), the surfactant concentration (X2), and soy lecithin concentration (X3), as well as to investigate the main effect, interaction effects, and quadratic effects of these formulation-ingredients on the dependent (response) factor: Entrapment Efficiency (Y1) and in-vitro% drug release (Y2). The independent variables and by combining the above components in variable concentrations (levels), 14 batches were created and evaluated based on the response.

Keywords: Ticagrelor, Cardiovascular, Optimization, Drug release

How to cite this article: Ahire Sujeetkumar Ishwarlal, Gupta Revathi A. Formulation, Optimization and Characterization of Ticagrelor Loaded NLCs Formulation. International Journal of Drug Delivery Technology. 2025;15(2):558-61. doi:10.25258/ijddt.15.2.24

REFERENCES

  1. Dana T, Pathan AK, Ahmad S. Enhancing Anticancer Potential: Optimization of Allicin Extraction from Regular Garlic and Characterization of Allicin-Loaded Copper Oxide Nanoparticles. International Journal of Drug Delivery Technology. 2024;14(2):1019-1031.
  2. Dwivedi S, Lalwani D, Sharma PK and Darwhekar GN. Advancing Oral Drug Delivery: The Impact of Solid Lipid Nanoparticles on Antiplatelet Therapy. European Journal of Parenteral and Pharmaceutical Sciences. 2025: 30(1):1-12.
  3. Herron GC, Bates ER. Review of the ticagrelor trials evidence base. Journal of the American Heart Association. 2024;13(11):e031606.
  4. Mikled P, Chavasiri W, Khongkow M. Development of dihydrooxyresveratrol-loaded nanostructured lipid carriers for safe and effective treatment of hyperpigmentation. Scientific Reports. 2024;14(1):29211.
  5. Ali, M.H., Alam, O., Ali, A., Ali, M.U., Parvez, S., Aldosari, E., Baboota, S. and Ali, J., 2024. Donepezil and Embelin loaded nanostructured lipid carriers for direct brain delivery as an intervention for alzheimer’s disease: Formulation design, optimization and evaluation. Journal of Cluster Science, 35(4):1021-1044.
  6. Abdulazeem L, Abd FG. Biosynthesis and Characterization of Gold Nanoparticles by Using Local Serratia spp. Isolate. International Journal of Pharmaceutical Quality Assurance. 2019;10(3):8-11.
  7. Mahajan PM, Jadhav SA, Hussain A, Chaturvedi P, Dwivedi S.Formulation Development and Evaluation of Silver Nanoparticles Containing Plant Extract. Nanotechnology Perceptions. 2024; 20(7): 3837-3842.