International Journal of Drug Delivery Technology
Volume 15, Issue 2

Development and Evaluation of a Topical Gel Containing 0.1% Adapalene and 2.5% Benzoyl Peroxide for Acne Treatment 

Ngan-Hanh-Thao Nguyen1, Dang-Khoa Nguyen2, Phu-Gia Tran3, Le-Duy Ly3, Minh-Tri Le3, Minh-Quan Le4, Van-Ha Nguyen4* 

1Faculty of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam

2Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam

3University of Health Sciences, Vietnam National University, Ho Chi Minh city 700000, Vietnam

4Faculty of Pharmacy, University of Medicine and Pharmacy at Ho Chi Minh city, Ho Chi Minh 700000, Vietnam 

Received: 11th Apr, 2025; Revised: 10th Jun, 2025; Accepted: 15th Jun, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

The gel product that combines two active ingredients adapalene (AD) and benzoyl peroxide (BO) has been used for a long time with good acne effectiveness and is licensed in the treatment of moderate to severe acne. On the market today, there are a few acne products containing these two active ingredients, however, the formula and preparation process have not been announced. Therefore, the study was conducted to research and prepare a gel product that combines AD 0.1% and BO 2.5%. The study results show that the gel formulation uses excipients Simugel SMS88 (6%), propylene glycol (4%), glycerin (4%), sodium docusate (0.05%), poloxamer 188 (0.2%). ) and demineralized water (83.15%) for a soft, pleasant physical sensation when applied, equivalent to a famous product (named X, which has the same ingredients and contents) in terms of parameters such as thinness, release of active ingredients, in vitro permeability . The results of stability monitoring under accelerated conditions for 6 months showed that the gel product had no significant physical or chemical changes. The research has successfully built the formula and process of preparing a gel product that combines the two active ingredients. The research results can be applied in upgrading larger batch sizes and deployed in production in the future.

Keywords: Adapalen, benzoyl peroxid, gel, simugel sms88, in vitro release, in vitro permeability

How to cite this article: Ngan-Hanh-Thao Nguyen, Dang-Khoa Nguyen, Phu-Gia Tran, Le-Duy Ly, Minh-Tri Le, Minh-Quan Le, Van-Ha Nguyen. Development and Evaluation of a Topical Gel Containing 0.1% Adapalene and 2.5% Benzoyl Peroxide for Acne Treatment. International Journal of Drug Delivery Technology. 2025;15(2):391-96. doi: 10.25258/ijddt.15.2.3

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