International Journal of Drug Delivery Technology
Volume 15, Issue 2

Formulation of Extended-Release Tablets using Natural Polymers as Matrix-Forming Agents for Sustained Drug Delivery

Deepali Jadhav1, Ranjit S Ambad2*, Roshan Kumar Jha2

1Dept. of Pharmacology Datta Meghe college of Pharmacy, Datta Meghe Institute of Higher Education and Research, Sawangi (M), Wardha. Maharashtra, India

2Department of Biochemistry, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Sawangi (M), Wardha, Maharashtra, India 

Received: 11th Mar, 2025; Revised: 15th Apr, 2025; Accepted: 3rd Jun, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

The oral route remains the most preferred method for drug administration due to its convenience and high patient compliance. However, conventional immediate-release formulations often lead to fluctuating plasma drug levels and require frequent dosing, which can impact adherence and therapeutic outcomes. This study focuses on the formulation and evaluation of extended-release (ER) tablets using natural polymers such as xanthan gum, guar gum, and sodium alginate as matrix-forming agents. These biodegradable and biocompatible polymers offer an eco-friendly alternative to synthetic materials, aligning with current trends in sustainable pharmaceutical development. The tablets were prepared using direct compression, with varying polymer concentrations, for pre- and post-compression parameters, including swelling behavior and in vitro drug release.

Keywords: Diclofenac Sodium, Metformin HCl, Microcrystalline cellulose (MCC), magnesium stearate, talc, lactose, extended-release, Korsmeyer-Peppas and drug delivery

How to cite this article: Deepali Jadhav, Ranjit S Ambad, Roshan Kumar Jha. Formulation of Extended-Release Tablets using Natural Polymers as Matrix-Forming Agents for Sustained Drug Delivery. International Journal of Drug Delivery Technology. 2025;15(2):680-83. doi: 10.25258/ijddt.15.2.39

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