International Journal of Drug Delivery Technology
Volume 15, Issue 2

32 Factorial Design Approaches for Development, Optimization and Characterization of Artemether Loaded Graphene Oxide Nanocomposites 

Harshali Sanjay Jadhav*, Gaurav Jain

Department of IES Institute of Pharmacy, Bhopal, Madhya Pradesh, India

Received: 23rd Feb, 2025; Revised: 17th Apr, 2025; Accepted: 27th May, 2025; Available Online: 25th Apr, 2025

ABSTRACT

Background: Artemether is antimalerial drug having shorter half-life. Conventional form of Artemether required frequent dosing for better pharmacological effect.

Objectives: Recently, graphene oxide-based nano-composition has drawn a lot of attention. The loading of drugs in graphine oxide nanostructure will show delay release behavior.

Methods: In this study, graphene oxide, which was produced using Hummer's technique, loaded with Artemether. The correlation of independence and dependant variables were identified using design of expert software.  Response surface methodology was engaged to improve formulation. Prepared Artemether  loaded graphine oxide nanocomposite were characterized by employing X-ray diffraction (XRD), entrapment efficiency, Differential scanning calorimetry, Fourier transform infrared spectroscopy (FTIR), and drug release.

Results: EE for each of the 13 experiments were from 69.58% to 85.78%. The FTIR spectra indicate the presence of Artemether in graphine oxide nanocomposites. Characteristic endothermic peak of Artemether  vanished in thermogram of Artemether in graphine oxide nanocomposites. The crystallinity of Artemether  decrease as indicate in the XRD peak. The release profile of the Artemether loaded graphine oxide nanocomposite formulation varied across all batches, ranging from 83.22% to 92.11%.

Conclusion: The developed AM in GO nanocomposites were seem to be favorable approche for sustained drug delivery of Artemether .

Keywords: Artemether, Graphene oxide(GO), Response Methodology, Delay release; Bioavailability.

How to cite this article: Harshali Sanjay Jadhav, Gaurav Jain. 32 Factorial Design Approaches for Development, Optimization and Characterization of Artemether Loaded Graphene Oxide Nanocomposites. International Journal of Drug Delivery Technology. 2025;15(2): 684-92. doi:10.25258/ijddt.15.2.40

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