International Journal of Drug Delivery Technology
Volume 15, Issue 2

Design, Development and Physicochemical Evaluation of Formulation for Gastroesophageal Reflux Disease

Ghugarkar Prasad Gorakshanath*, Kadam Pallavi Kanifnath 

Dr. N. J. Paulbudhe College of Pharmacy, Ahmednagar, India 

Received: 19th Mar, 2025; Revised: 19th May, 2025; Accepted: 5th Jun, 2025; Available Online: 25th Jun, 2025

ABSTRACT

The present study mainly involves the targeting the gastro intestinal ulcer by using Rabeprazole formulation. In this main strategy contains the formulation and optimisation of Rabeprazole pellet formulation. The stomach is the primary acidic environment in which nearly all drugs that inhibit proton pumps breakdown. The strategy involve is to coat the Rabeprazole pellet formulation with polymer coat which release the formulation in appropriate site only. Pre formulation date of material detected. Compatibility study of drug with selected excipients was analysed by using Fourier Transform Infrared Spectroscopy. Thermal study of the Rabeprazole was analysed by using differential scanning calorimetry instrument. Purity of the Rabeprazole was detected by using different physical and chemical characters as well as by using ultra violet spectrometry. For core pellet formulation of Rabeprazole, Extruder and Spheroniser method was used. After core pellet formulation it was seal coated with Opadry seal coat material. Lastly seal coated pellet of Rabeprazole was coated by using Eudragit polymer for site specific drug delivery. Eudragit inhibits the release of formulation in acidic condition. Evaluation parameters detected on optimised batch. Stability study was performed as per International Council for Harmonisation guideline.

Keywords: Peptic Ulcer, Stomach, Dissolution, Intestine.

How to cite this article: Ghugarkar Prasad Gorakshanath, Kadam Pallavi Kanifnath. Design, Development and Physicochemical Evaluation of Formulation for Gastroesophageal Reflux Disease. International Journal of Drug Delivery Technology. 2025;15(2): 693-97. doi:10.25258/ijddt.15.2.41

REFERANCES

  1. Tegk SM, Rlc RA. Formulation and evaluation of esomeprazole fast dissolving buccal films. Asian Journal of Pharmaceutical and Clinical Research. 2018;11(10):193. DOI 15159/ajpcr.11.4.18
  2. Alshammari E. Irrational Prescribing Habit of Omeprazole. International Journal of Pharmaceutical Quality Assurance. 2019;10(4): 578-582. DOI: 10.25258/ijpqa.10.4.3
  3. Abdullah EH, Rashid QN. Spectrophotometric Determination of Esomepreazol in Pure form and in its Pharmaceutical Preparations. International Journal of Drug Delivery Technology. 2021;11(1):42-46. DOI: 10.25258/ijddt.11.1.7.
  4. Ghugarkar PG, Khulbe P. Formulation, Development, Evaluation and Optimisation of pH Dependent Drug Delivery System Containing Proton Pump Inhibitor. International Journal of Pharmaceutical Quality Assurance. 2022;13(1):21-25. DOI: 10.25258/ijpqa.10.4.3.
  5. Archana V, Subhash T. Formulation and development of solid oral dosage form of millet and evaluation of Antiulcer Activity using ethanol Induced Ulcer in Rat. International Journal of Drug Delivery Technology. 2025;15(1):244-53. doi: 10.25258/ijddt.15.1.34
  6. Prasanna GR, Srikanth G, 2019. Formulation and Evaluation of Colon Specific Drug Delivery of Press Coated Esomeprazole Tablets, Journal of Drug Delivery and Therapeutics, 9(1):9-16.
  7. Naveen KY. Formulation Development and Invitro Evaluation of Esomeprazole Controlled Release Tablets by Using Various Grades of Eudragit Polymers. Indo American Journal of Pharmaceutical Research.2017:7(01).
  8. Rakesh S, Swarnlata S, 2018. Spectrophotometric Estimation of Omeprazole in Pharmaceutical Dosage Form, Research J. Pharm. and Tech. 1(3); Page 276-277.
  9. Sirisha M and Arifa B, 2016. Formulation and evaluation of omeprazole nanoparticles by using natural polymers, The Pharma Innovation Journal ; 5(10): 111-117.
  10. Rathi SG, Patel DJ, Shah SK and Joshi BY, 2020. Formulation and evaluation of lansoprazole and domperidone mouth dissolving tablets. Int J Pharm Sci & Res, 11(12): 6402-12.
  11. Haneesha SK, Venkataramana M, Ramarao N, 2020. Formulation and evaluation of lansoprazole loaded enteric coated microspheres, Int. J. Res. Pharm. Sci & Tech., 1(4), 124-130.