International Journal of Drug Delivery Technology
Volume 15, Issue 2

Formulation Development and Characterization of Pullulan Based Quetiapine Fumarate Oral Films

Venu Babu Chennupati1,2*, Venkata Ramana Murthy Kolapalli2 

1Bapatla college of pharmacy, Bapatla, Andhra Pradesh, India

2A.U college of pharmaceutical sciences, Andhra  university, Vishakapatnam, Andhra Pradesh, India 

Received: 3rd Mar, 2025; Revised: 24th Apr, 2025; Accepted: 25th May, 2025; Available Online: 25th Jun, 2025

ABSTRACT

Quetiapine fumarate is one of the major FDA approved drug in treatment of schizophrenia. Since this drug was having very low bioavailability of 9% and extensive metabolism in liver, it was selected as a suitable drug candidate for our study. This work’s objective was to formulate quetiapine fumarate oral films as alternate dosage form to tablets. All the formulations composed of pullulan as film forming agent and glycerine as plasticizer. The experimental runs were generated by central composite design using MINITAB. The concentration of polymer (300-350mg) and plasticizer (40-50 mg) were altered with in the design space limits. Solvent casting method was adopted for casting the films. Studies on the compatibility of drug excipients were conducted by FTIR analysis and also the surface morphology was studied by SEM analysis. All the film shows good mechanical properties. The other evaluation parameters like surface pH, film thickness, disintegration time and uniformity of weight were evaluated and found within the acceptable limits. Drug release kinetic data shows that all the formulations follow first order release kinetics. Finally concludes that the developed films are expected to increase patient acceptance and the method was also easily adoptable in large scale industries.

Keywords: Quetiapine fumarate, oral films, pullulan, glycerine

How to cite this article: Venu Babu Chennupati, Venkata Ramana Murthy Kolapalli. Formulation Development and Characterization of Pullulan Based Quetiapine Fumarate Oral Films. International Journal of Drug Delivery Technology. 2025;15(2):698-704. doi: 10.25258/ijddt.15.2.42

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