International Journal of Drug Delivery Technology
Volume 15, Issue 2

Pharmacological Investigations of Corchorus trilocularis and Cressa cretica Medicinal Plant for Hepatoprotective Activity 

Purnendra Kumar Gupta*, Vivek Chourasia 

Faculty of Pharmacy, Mansarovar Global University, Sehore Madhya Pradesh, India

Received: 12th Apr, 2025; Revised: 19th May, 2025; Accepted: 2nd Jun, 2025; Available Online: 25th Jun, 2025

ABSTRACT

In albino rats that had been exposed to carbon tetrachloride-induced hepatotoxicity, the antioxidantand hepatoprotective properties of the ethanolic extract of Corchorus trilocularis and Cressa Cretica leaves were investigated. Biochemical markers such total protein (TP), total albumin (TA), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphate enzyme (ALKP), whole blood levels, and bilirubin were estimated in order to determine the level of resistance. In vitro and in vivo lipid peroxidation generated by CCl4 was also inhibited by the extract. Rats exposed to hazardous dosages of ethanol extract in carbon tetrachloride (200 and 400 mg/kg body weight) had notable hepatoprotective effects. The extract's hepatoprotective properties were evaluated against a conventional dose of silymarin (10 mg/kg body weight IP).

Keywords: Corchorus trilocularis and Cressa Cretica, Hepatoprotective Activity, Silymarin, Carbon tetra chloride.

How to cite this article: Purnendra Kumar Gupta, Vivek Chourasia. Pharmacological Investigations of Corchorus trilocularis and Cressa cretica Medicinal Plant for Hepatoprotective Activity. International Journal of Drug Delivery Technology. 2025;15(2):705-08. doi: 10.25258/ijddt.15.2.43

REFERENCES

  1. Meyer SA, Kulkarni AP. Hepatotoxicity. In: Hodgson E, Smart RC, editors. Introduction to Biochemical Toxicology.3rd ed. New York: John Wiley and sons; 2001. pp. 487–490.
  2. Guntupalli M, Chandana V, Pushpangadan P, Shirwaiker AI. Hepatoprotective effects of rubiadin, a major constituent of Rubiacordifolia Linn.  Ethnopharmacol. 2006; 103:484–490.
  3. A Sharma, B Sangameswaran, V Jain, M S Saluja Hepatoprotective activity ofAdina cordifolia against ethanol induce hepatotoxicity in rats. International Current Pharmaceutical Journal .2012; 1(9): 279-284.
  4. Akram Eidi1, Pejman Mortazavi, Maryam Bazargan1, Jalal Zaringhalam. Hepatoprotective activity of cinnamon ethanolic extract against CCL4-induced liver injury in rats. Excli Journal .2012; 11:495-507.
  5. Kim C., Sin M., Ahn D., Lee K. 1999. Chinese Materia Medica Grand Dictionary 1st ed., Jeongdam Publishing Company, Chopra K., Kaur, G., Tirkey N., 2006. Beneficial effect of hesperidin on lipo polysaccharide-induced hepatotoxicity. Toxicology 226,152–160.
  6. Zakaria Z. A., Abdul Ghani Z. D., Raden Mohd Nor R. N., Gopalan H. K., Sulaiman M. R., Mat Jais A. M., Abdullah F. C.2007. Antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract in experimental animal models. Yakugaku Zasshi 127: 359–365. doi: 10.1248/yakushi.127.359
  7. O Saxena and M. Brahman, The Flora of Orissa, Capital Business Services and Consultancy, Bhubaneswar, India(1995)
  8. D. Prajapati, S. S. Purohit, A. K. Sharma, and T. Kumar, A Handbook of Medicinal Plants (Complete Source Book), Agrobios Ltd., India (2004).
  9. K. Warrier, V. P. K. Nambier, and C. Ramankutty, Indian Me-dicinal Plants (Compendium of 500 Species), CSIR, New Delhi,India (1990).
  10. Shahat, N. S. Abdel-Azim, and F. M. Hammouda, Years of Natural Products Research: Past, Present and Future, Amster-dam (1999 – 2000).
  11. Kamboj Pradeep et al (2010) Antihyperlipidemic effect of hydroalcoholic extract of Kenaf (Hibiscus cannabinus ) leaves in high fat diet fed rats. vol1 (3): 174-181.
  12. Harborne JB. Phytochemical Methods.3rd ed. UK: Chapman and Hall; 1998. pp. 137–139.
  13. Gao X, Ohlander M, Jeppsson N, Bjork L, Trajkovski V. Changes in antioxidant effects and their relationship to phytonutrients in fruits of sea buckthorn (Hippo phaerhamnoides L.  Agric. Food Chem. 2000; 48:1485–1490.
  14. Kosalec I, Bakmaz M, Repeliniak S, Vladimir- knezevic S. Quantitative analysis of the flavonoids in raw propolis from northern Croatia. Acta Pharma. 2004; 54:65–72.
  15. Woolson RF. Statistical Methods for the Analysis of Biomedical Data.New York: John Wiley and Sons Inc; 1987. pp. 172–174.