International Journal of Drug Delivery Technology
Volume 15, Issue 2

Pharmacological Activity of Manilkara hexandra and Stereospermum colais Buch Leaves Extract for CNS Disorders in Mice 

Amit Kumar Agrahari*, Vivek Chourasia 

Faculty of Pharmacy, Mansarovar Global University, Sehore Madhya Pradesh, India

Received: 17th Apr, 2025; Revised: 19th Jun, 2025; Accepted: 10th Jun, 2025; Available Online: 25th Jun, 2025

ABSTRACT

Depression is a major mental illness worldwide. It is also difficult to identify patients with multiple stressors. For thousands of years, traditional medicine has used many medicinal plants to treat stress due to their effectiveness, efficacy, and safety. This aimed to screening the anxiolytic effect of ethanolic extracts of Manilkara hexandra and Stereospermum colais Buch leaves in rats such as mice. Anxiolytic activity was evaluated in Swiss albino rats. Leaves of Manilkara hexandra and Stereospermum colais Buch plants are dried and crushed to coarse powder. This method was used for this stress study by using Soxhlet extraction. A phytochemical qualitative analysis of ethanolic extracts of Manilkara hexandra and Stereospermum colais Buch was carried out. Lots of models were used for screening the anxiolytic effect of Manilkara hexandra and Stereospermum colais Buch plant leaves: enhancement plus maze model, social model, light-dark model, and whole plate process. For this purpose hydroalcoholic extract is administered orally400 and 300 mg/kgwere selected respectively, as the anxiolytic standard drug diazepam (2 mg/kg) was used. According to the research results, ethanolic extracts of Manilkara hexandra and Stereospermum colais Buch leaves show anxiolytic activity in reducing aversive fear. Studies have shown that hydroalcoholic extracts of Manilkara hexandra and Stereospermum colais Buch leaves have anxiolytic effects. Data show that hydroalcoholic extracts of Manilkara hexandra and Stereospermum colais Buch leaves have anxiolytic properties compared to control.

Keywords: Manilkara hexandra and Stereospermum colais Buch, CNS Disorders Activity, Diazepam, Ethanolic Extracts.

How to cite this article: Amit Kumar Agrahari, Vivek Chourasia. Pharmacological Activity of Manilkara hexandra and Stereospermum colais Buch Leaves Extract for CNS Disorders in Mice. International Journal of Drug Delivery Technology. 2025;15(2):709-13. doi: 10.25258/ijddt.15.2.44

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