International Journal of Drug Delivery Technology
Volume 15, Issue 2

Exploring Locust Bean Gum and Thiolated Chitosan Hydrogels for Sustained Delivery of Telmisartan in Hypertension Treatment: An In Vivo Study 

V Mohanraj, M Komala

Department of Pharmaceutics, Vels Institute of Science, Technology & Advanced Studies, Chennai, India 

Received: 29th Mar, 2025; Revised: 24th Apr, 2025; Accepted: 15th May, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

This article outlines development of a mucoadhesive hydrogel composed of thiolated chitosan and Locust Bean Gum for targeted transport of telmisartan. Hydrogel was prepared by tri-polyphosphate ionotropic gelation cross-linking method. Optimized formulation was evaluated in a preclinical study using a hypertension-induced rat model, comparing it to free telmisartan. Research showed that oil-entrapped beads loaded with TEL had a relative bioavailability of 151.59%, 1.52 times greater than the pure TEL suspension. It appears that the new method of drug delivery using oil-entrapped beads loaded with transdermal ligands improves patient compliance by increasing drug solubility, oral bioavailability, and therapeutic effectiveness. Further, the formulation's anti-hypertensive effects were verified to be substantially prolonged in animal models by in vivo pharmacodynamic tests.

Keywords: Locust gum, telmisartan, IPN hydrogel, anti-hypertertensive study, thiolated chitosan

How to cite this article: V Mohanraj, M Komala. Exploring Locust Bean Gum and Thiolated Chitosan Hydrogels for Sustained Delivery of Telmisartan in Hypertension Treatment: An In Vivo Study. International Journal of Drug Delivery Technology. 2025;15(2):812-17. doi: 10.25258/ijddt.15.2.57

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