International Journal of Drug Delivery Technology
Volume 15, Issue 2

Integrative Approaches in Hypertension Management: A Review of the Combination of Allopathic Drugs and Herbal Medicines in Drug Delivery Systems 

Shital A Shinde1*, Dipak P Mali1, Vandana M Thorat2, Ankita D Walgude3 

1*Krishna Institute of Pharmacy, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India

2Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, Maharashtra, India

3Rajgad Dnyanpeeth’s College of Pharmacy, Bhor, Maharashtra, India

Received: 17th Nov, 2024; Revised: 21st Feb, 2025; Accepted: 19th Mar, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

Hypertension remains an important worldwide fitness distress, requiring development of integrative medicinal approaches to improve action outcomes. This review explores the synergistic combination of allopathic antihypertensive drugs and herbal medicines within drug delivery systems (DDS) to improve efficacy, minimize adverse effects, and optimize patient adherence. By leveraging modern DDS technologies such as controlled-release systems, nano formulations, and liposomes, the bioavailability and targeted delivery of both pharmaceutical and herbal compounds can be significantly enhanced. The review begins by discussing the global impact of hypertension, highlighting the need for complementary therapies and defining the concept of allopolyherbal formulations. It then examines the pharmacological mechanisms of conventional antihypertensive drugs and herbal medicines, focusing on their potential for synergistic interactions. The role of DDS in addressing challenges related to bioavailability is explored, with emphasis on nanotechnology, polymeric carriers, and targeted drug delivery. The clinical efficacy and safety of combining allopathic and herbal medicines are reviewed, incorporating recent clinical trial evidence and safety considerations such as herb-drug interactions, standardization issues, and regulatory challenges. Furthermore, the application of allopolyherbal formulations in hypertension management is assessed, with discussions on future trends, including personalized medicine and smart drug delivery systems. The review concludes by emphasizing the importance of integrating advanced pharmacovigilance frameworks and evidence-based regulatory strategies for assured of safety as well as efficient adoption of formulations. By addressing key pharmacological, technological, and regulatory aspects, this integrative approach offers a promising strategy to enhance hypertension treatment and patient outcomes.

Keywords: Integrative hypertension management, allopolyherbal formulations, drug delivery systems (DDS), synergistic interactions, and nanotechnology in drug delivery.

How to cite this article: Shital A Shinde, Dipak P Mali, Vandana M Thorat, Ankita D Walgude. Integrative Approaches in Hypertension Management: A Review of the Combination of Allopathic Drugs and Herbal Medicines in Drug Delivery Systems. International Journal of Drug Delivery Technology. 2025;15(2):825-38. doi: 10.25258/ijddt.15.2.59

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