International Journal of Drug Delivery Technology
Volume 15, Issue 2

Invasomes: A Novel Transdermal Approach for Antifungal Drug Delivery

Shivaji Patil, Sushil Bhargav

Department of Pharmaceutical Sciences, Madhav University, Abu road, Pindwara, Dist Sirohi -307026, Rajasthan, India 

Received: 24th Feb, 2025; Revised: 29th Mar, 2025; Accepted: 23rd Apr, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

Management of fungal infections, for those affecting skin, has faced challenges in poor penetration and efficacy. Traditional topical antifungal therapies often show limited results due to the skin’s barrier properties. Invasomes, has emerged as a greater tactic to improve drug penetration through skin, improving penetration and effectiveness of antifungal drugs. This review comprehensively analyzes invasomes as a transdermal drug delivery system specifically for antifungal therapies. It covers structure, composition, and mechanism of action of invasomes, Focusing on their advantages over conformist drug delivery systems. Key factors influencing invasome efficacy, such as the incorporation of phospholipids, ethanol, and terpenes, are discussed in detail. Invasomes significantly improve drug permeation through skin due to their flexible lipid bilayer structure and presence of ethanol and terpenes, which disrupt skin’s lipid matrix. Various studies have demonstrated the potential of invasomes in delivering antifungal drugs more effectively than conventional topical formulations. The increased drug bioavailability and improved therapeutic outcomes underscore the utility of invasomes. Invasomes characterize a capable transdermal delivery system for antifungal drugs, offering improved drug permeation, stability, and therapeutic efficacy. Their ability to overcome the skin barrier makes them an alternative to traditional topical formulations.

Keywords: Invasomes, Transdermal drug delivery, Antifungal drug delivery, Vesicular systems, Skin penetration enhancers, Phospholipid-based vesicles, Terpenes in drug delivery.

How to cite this article: Shivaji Patil, Sushil Bhargav. Invasomes : A Novel Transdermal Approach for Antifungal Drug Delivery. International Journal of Drug Delivery Technology. 2025;15(2):867-74. doi: 10.25258/ijddt.15.2.63

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