International Journal of Drug Delivery Technology
Volume 15, Issue 2

Improving Solubility and Dissolution Characteristics of Dapoxetine Hydrochloride through the Liquisolid Compact Method

Nagineni Sudarshan Rao1, Rama Rao Vadapalli1, Brahmaiah Bonthagarala1*, Jalluri Charishma Vasavi2, Mallabathula Meghana2

1Department of Pharmaceutics, Shri Vishnu College of Pharmacy (Autonomous),Vishnupur, Bhimavaram-534202, Andhra Pradesh, India

2Department of Pharmaceutical Quality Assurance, Shri Vishnu College of Pharmacy (Autonomous),Vishnupur, Bhimavaram-534202, Andhra Pradesh, India 

Received: 31st Jan, 2025; Revised: 17th Mar, 2025; Accepted: 18th Apr, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

This study aimed to enhance the solubility and dissolution properties of Dapoxetine hydrochloride (DXH) tablets by using of novel method i.e., liquisolid compact technology (LCT).  A total of 9 formulations of DXH tablets were prepared by using carrier materials like microcrystalline cellulose and coating materials like lactose, silica, and starch. In out of nine formulations Super disintegrants like cross povidone (CP) in F1–F4 and Cross Carmellose Sodium in F5–F9 added. All formulations were evaluated for both pre compressional and post compressional evaluation parameters. Based on the evaluation parameters, the F6 formulation exhibited superior dissolution characteristics compared to others, indicating enhanced solubility rates. In vitro dissolution studies showed significantly improved release rates for DXH tablets.X-ray diffraction (XRD) analysis revealed a reduction in crystallinity, further supporting enhanced dissolution. Scanning electron microscopy (SEM) confirmed uniform dispersion of drug particles in the optimized formulation, leading to improved drug release. The absence of notable interactions between the drug and excipients was confirmed via FTIR analysis, ensuring formulation stability. In conclusion, LCT effectively enhanced the dissolution rate of DXH, demonstrating its potential as a promising approach for improving poorly water-soluble drugs.

Keywords: Liquisolid compact technology (LCT), Dapoxetine hydrochloride (DXH), Solubility, Dissolution Rate, FTIR

How to cite this article: Nagineni Sudarshan Rao, Rama Rao Vadapalli, Brahmaiah Bonthagarala, Jalluri Charishma Vasavi, Mallabathula Meghana. Improving Solubility and Dissolution Characteristics of Dapoxetine Hydrochloride Through the Liquisolid Compact Method. International Journal of Drug Delivery Technology. 2025;15(2):425-32. doi: 10.25258/ijddt.15.2.7

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