International Journal of Drug Delivery Technology
Volume 15, Issue 2

Preformulation Studies of Bergenin: A Primary Step in Future Designing of Novel Drug Delivery System 

Urvashi Sharma*, Sanjay Jain

Faculty of Pharmacy, Medi-Caps University, Rau, Indore, Madhya Pradesh, 453331, India 

Received: 16th Jan, 2025; Revised: 2nd Feb, 2025; Accepted: 30th Apr, 2025; Available Online: 25th Jun, 2025 

ABSTRACT

Preformulation studies are an essential stage in drug development, focused on elucidating the physicochemical and pharmacokinetic characteristics of a drug candidate to inform formulation design. Bergenin, a naturally occurring C-glucoside derivative of gallic acid, demonstrates a diverse array of pharmacological properties, encompassing anti-inflammatory, hepatoprotective, antiviral, and antidiabetic effects. Nonetheless, the effective incorporation of bergenin into an appropriate drug delivery system requires an extensive preformulation analysis. This research work was done with an objective to investigate the preformulation assessment of bergenin to evaluate its solubility in different solvents, compatibility, and crystallinity. The structural elucidation was done using FTIR spectroscopy and the X-ray diffraction (XRD) analysis validated the crystalline characteristics of bergenin, indicating a possible requirement for amorphization or particle size reduction methods to improve dissolving rates. Compatibility studies of drugs and excipients utilizing Fourier-transform infrared spectroscopy (FTIR) determined appropriate excipients for stable formulation. The results underscore significant problems, including inadequate solubility and crystallinity, that necessitate resolution via sophisticated formulation techniques such as solid dispersions or nanoencapsulation.

Keywords: Preformulation, Bergenin, Solubility, Crystallinity

How to cite this article: Urvashi Sharma, Sanjay Jain. Preformulation Studies of Bergenin: A Primary Step in Future Designing of Novel Drug Delivery System. International Journal of Drug Delivery Technology. 2025;15(2): 439-43. doi:10.25258/ijddt.15.2.9

REFERENCES

  1. Desu, P.K., Vaishnavi, G., Divya, K., Lakshmi, U. An overview on Preformulation studies. Indo American Journal of Pharmaceutical Sciences. 2015; 2(10): 1399-1407.
  2. Kengar, M., Howal, R., Aundhakar, D., Nikam, A., Hasabe, P. Physico-chemical Properties of Solid Drugs: A Review. Asian Journal of Pharmacy and Technology. 2019; 9(1): 53-9.
  3. Ahirwar, K., Shukla, R. Preformulation Studies: A Versatile Tool in Formulation Design. Drug Formulation Design. 2023; Publisher: IntechOpen, In book: Drug Formulation Design
  4. Bajpai, V. K., Shukla, S., Kang, S. C. Bergenin: A review of its pharmacological properties and therapeutic potential. Journal of Pharmacognosy and Phytochemistry. 2021; 10(2), 101-113.
  5. Singh, R., Kumar, A., & Chauhan, S. Recent advances and applications of bergenin in drug discovery. Phytomedicine Reviews, 2020; 24(5), 150-160.
  6. Deepika, Kaur, B., Gupta, M. HPLC Method Development and Validation for the Simultaneous Estimation of Pitavastatin and Telmisartan. Journal of Pharmaceutical Research and Reports. 2023; (4)140.
  7. Anusha, V., Umashankar, M.S., Kumar, Y.G. Preformulation Studies of Pitavastatin Calcium– A Primary, Step in Further Design of Chronotherapeutic Formulation Synchronized with Circadian Rhythm. International Journal of Drug Delivery Technology. 2024;14(3):1578-1585.
  8. Sharma, U., Agrawa, S., Chhajed, M., & Dwived, S. Improved dissolution and solubility characteristics of clopidogrel bisulphate using gelucire 44/14. European Journal of Parenteral and Pharmaceutical Sciences. 2024; 291.
  9. Resmi DS. Formulation and Evaluation of Topical Econazole Nitrate Microsponge Loaded Hydrogel. Ijppr. 2018; 12 (1): 27-64.
  10. Yadav PK, Swami H. Preformulation: Development of Solubility, UV and FTIR estimation of Phytobioactive Antifungal Compounds Allicin. International Journal of Pharmaceutical Quality Assurance. 2023;14(4):1055-1057
  11. Ganesh BSP, Darna B. Development and In vivo Evaluation of Pitavastatin Self-Emulsifying Drug Delivery Systems. International Journal of Pharmaceutical Sciences and Drug Research. 2021; 13(3):295-302.
  12. Chauhan S, Dwivedi A. Preformulation Studies, UV Spectral and FTIR Analysis of Allicin. International Journal of Pharmaceutical Quality Assurance. 2024;15(3):1168-1170.
  13. Sharma, U., Joshi, A., Vyas, N., Malviya, S., & Kharia, A. Solubility Enhancement of Clopidogrel Bisulfate by Solid Dispersion Technique using Carboxymethylcellulose Sodium and Xanthan Gum. Journal of Drug Delivery and Therapeutics. 2017; 7(7), 35-37.
  14. Sivapriya, S., Prabhakaran, L., Venkatesan, P. Evaluation of Drug-Excipient Compatibility for Paroxetine Nanoformulations using DSC and FTIR Analysis. YMER. 2024. 23(12): 858-865.
  15. Akhter, M. H., Al-Keridis, L. A., Saeed, M., Khalilullah, H., Rab, S. O., Aljadaan, A. M., Rahman, M. A., Jaremko, M., Emwas, A.-H., Ahmad, S., Alam, N., Ali, M. S., Khan, G., & Afzal, O. (2023). Enhanced drug delivery and wound healing potential of berberine-loaded chitosan–alginate nanocomposite gel: Characterization and in vivo assessment. Frontiers in Public Health, 11, 1238961.