International Journal of Drug Delivery Technology
Volume 15, Issue 3

Formulation and Characterization of Niosomal Gel for Topical Treatment of Psoriasis

Mansi Gupta*, Sarika Shrivastava, Jitendra Banweer

Sanjeev Agrawal Global Educational University, Bhopal, MP-462022, India

Received: 9th Jun, 2025; Revised: 16th Jul, 2025; Accepted: 29th Aug, 2025; Available Online: 25th Sep, 2025

ABSTRACT

The aim of the research work was to formulate and characterize the Calcipotriol loaded niosomal gel for the topical treatment of psoriasis through application of different polymers. Psoriasis is a chronic skin condition in which the skin develops areas that become thick and covered with silvery scales. For psoriasis treatment, topical application is preferred in spite of other dosage form. Use of Fourier transform infrared Spectroscopy (FT-IR) showed that Calcipotriol was compatible with other excipients in terms of its physical and chemical nature. The gels formulated were analysed for their viscosity, extruding potential, drug content, test of skin irritation, pH of final formulation, along with its stability and in-vitro diffusion profile. The process includes the release of Calcipotriol from all prepared formulations by using dialysis membrane in the pH 6.8 phosphate buffer at 37°C temperature. This characterization study allowed to select the optimized batch from among the formulations prepared. From the data gathered it was ascertained that Calcipotriol has the potential in being used in gel formulation for the therapeutic management of psoriasis.

Keywords: Psoriasis, Calcipotriol, niosomal gel, topical therapy, carbopol, HPMC

How to cite this article: Mansi Gupta, Sarika Shrivastava, Jitendra Banweer. Formulation and Characterization of Niosomal Gel for Topical Treatment of Psoriasis. International Journal of Drug Delivery Technology. 2025;15(3):1077-81. doi: 10.25258/ijddt.15.3.23

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