International Journal of Drug Delivery Technology
Volume 15, Issue 3

Development and Optimization of Canagliflozin-Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using Box-Behnken Design: In-vitro and Stability Evaluation 

Sunismita Sahu1*, Ranjit Mohapatra2, Amiyakanta Mishra3, Santosh Kumar Mahapatra3 

¹Research Scholar, University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Odisha-751004, India

2University Department of Pharmaceutical Sciences, Utkal University, Bhubaneswar, Odisha-751004, India

3College of Pharmaceutical Sciences, Puri, Bidyaniketan, Puri-Konark Marine Drive Road, Puri, Odisha-752004, India 

Received: 7th Jun, 2025; Revised: 24th Jul, 2025; Accepted: 17th Aug, 2025; Available Online: 25th Sep, 2025 

ABSTRACT

The goal of this work was to improve the solubility, permeability, and therapeutic effectiveness of canagliflozin, a weakly water-soluble antidiabetic medication, by creating and refining a transdermal patch based on a self-nanoemulsifying drug delivery system (SNEDDS). Transdermal administration guarantees continuous drug release, enhances patient compliance, and avoids first-pass metabolism. Tween 20, caprylic acid, and groundnut oil were shown to be the best excipients by solubility screening. The formulation variables were optimized using a Box-Behnken design and a pseudo-ternary phase diagram. With a globule size of 142.9 nm, a PDI of 0.420, and a zeta potential of −27.0 mV, the optimized SNEDDS, which included 1.68 g groundnut oil, 0.7663 g Tween 20, and 0.1573 g caprylic acid, had good physical stability and homogeneity. FTIR, DSC, and XRD confirmed drug-excipient compatibility and the amorphous nature of the formulation. The SNEDDS was successfully incorporated into a transdermal patch and demonstrated excellent emulsification efficiency. The developed system offers a promising non-invasive platform for sustained canagliflozin delivery, potentially improving its bioavailability and clinical effectiveness in managing type 2 diabetes mellitus.

Keywords: Canagliflozin; Self-nanoemulsifying drug delivery system (SNEDDS); Transdermal patch; Box-Behnken design; Nanoemulsion; Drug permeability; Diabetes mellitus; Optimization.

How to cite this article: Sunismita Sahu, Ranjit Mohapatra, Amiyakanta Mishra, Santosh Kumar Mahapatra. Development and Optimization of Canagliflozin-Loaded Self-Nanoemulsifying Drug Delivery System (SNEDDS) Using Box-Behnken Design: In-vitro and Stability Evaluation. International Journal of Drug Delivery Technology. 2025;15(3):1162-68. doi: 10.25258/ijddt.15.3.35

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