International Journal of Drug Delivery Technology
Volume 15, Issue 3

Formulation and Evaluation of MUPS Capsules and Tablets Containing Coated Pellets of Tolbutamide, Saxagliptin, and Verapamil

Shishupal S Bodhankar*, Mohini Sihare

Department of Pharmaceutical Science, Oriental University Indore (M.P.), India 

Received: 19th Jul, 2025; Revised: 24th Aug, 2025; Accepted: 4th Sep, 2025; Available Online: 25th Sep, 2025 

ABSTRACT

The current study emphases on development and assessment of MUPS capsules and tablets incorporating coated pellets of three drugs Tolbutamide, Saxagliptin, and Verapamil targeted for combined therapeutic management of diabetes and hypertension. The coated pellets were formulated to achieve controlled and sustained drug release, enhancing bioavailability and minimizing drug-drug interactions. Pellet coating used several polymers to customize the release profile of each medication. The generated pellets were examined for their in-vitro dissolving behavior, medication content, particle size, and form. Crushed MUPS pills were made by inserting the coated pellets inside capsules. Next, the disintegration time, flow properties, tablet hardness, friability, and drug release kinetics were assessed. Because of their stable, uniform drug release, and sufficient mechanical strength, the improved MUPS formulations shown potential as efficient oral dosage forms for combination therapy. This method might be used to give patients several different drugs in one dosage form, which could help them stick to their therapy and get better outcomes.

Keywords: Multiple Unit Pellet System, Capsules, Tablets, Pellets

How to cite this article: Shishupal S Bodhankar, Mohini Sihare. Formulation and Evaluation of MUPS Capsules and Tablets Containing Coated Pellets of Tolbutamide, Saxagliptin, and Verapamil. International Journal of Drug Delivery Technology. 2025;15(3):1272-78. doi: 10.25258/ijddt.15.3.48

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