International Journal of Drug Delivery Technology
Volume 15, Issue 3

Design, Development and Evaluation of Telmisartan and Azelnidipine Loaded Multiparticulate Pulsatile Drug Delivery System

Anil V Chandewar, Ranjeet N Ade*, Nitin I Kochar 

Department of Pharmaceutical Sciences, Pataldhamal Wadhwani College of Pharmacy, Dhamangaon Road, Yavatmal-445001 (M. S.), India

Received: 7th Jun, 2025; Revised: 15th Jul, 2025; Accepted: 26th Jul, 2025; Available Online: 25th Sep, 2025

ABSTRACT

This study aimed to design, develop, and assess multiparticulate pulsatile drug delivery for the

chronotherapeutic administration of Azelnidipine and Telmisartan. PVP K- 30 has been employed as a binder in the result layering fashion for manufacturing the drug- loaded bullets (pallets). The polymer affect amalgamation of Eudragit RS 100 and RL 100 at varying composition was applied to the drug- loaded peerless globules using a amalgamation of IPA:DCM (7:3), triethyl citrate (TEC) as a plasticizer, and talc as an anti-sticking agent. The set bullets (pellets) were also estimated for FTIR, Flow properties, friability, medicine (drug) content, SEM and in vitro dissolution study. FTIR study reveals no commerce between drug and polymer. SEM study vindicated the smooth appearance of coating over the surface of pellets. Pallets carpeted with 10% polymer coating weight gain showed promising lag-time and detention drug release. Batch F6 prepared with 60:40 rate of eudragit RS and RL 100 polymer gives total lag time of 4 hrs and drug release in 8 hr. The stability of the farther bettered carpeted pellet expression was excavated. After three months of storage at 45 °C/ 75% RH, expression F7 was set up to have no distinguishable changes in its physical appearance, drug content, or in- vitro dissolution pattern.

Keywords: Telmisartan, Azelnidipine, Eudragit, Solution Layering technique, Pulsatile Drug delivery system, etc.

How to cite this article: Anil V Chandewar, Ranjeet N Ade, Nitin I Kochar. Design, Development and Evaluation of Telmisartan and Azelnidipine Loaded Multiparticulate Pulsatile Drug Delivery System. International Journal of Drug Delivery Technology. 2025;15(3):1310-17. doi: 10.25258/ijddt.15.3.52

REFERENCES

  1. Jain D., Ratuja R, Jain V., Bansal P., Singh. Recent technologies in pulsatile drug delivery. Biomatter.2011;1:1, 1-9.
  2. Raghavendrarao NG., Soumya P, Revathi A., Nayak SB . A review on pulsatile drug delivery system. International Research Journal of Pharmacy. 2013; 4 (3):31-44..
  3. Latha K M U Uhumwangho S A Sunil RamanaSreekanth K V Murthy Chronobiology and chronotherapy of hypertension-A review International Journal of Health Research, 2010; 3(3): 121-131
  4. Kaur M., Bala R. Chronotherapy : A review. Int J Pharm Sci Res2013;4(1):90-102.
  5. Sarkhejiya NA, Praful DB. Newer insights into pulsatile drug delivery systems. WJPS 2017;5:134-50
  6. Rompicharla B, Prabha KS, Tabasum M. A comprehensive review ofpulsatile drug delivery system. Int Res J Pharm 2012;3:106-8.
  7. Chaudhari MP, Chaudhari DP. Formulation and evaluation of multiparticulate system for chronotherapeutic delivery of salbutamolsulphate. J Pharm BioallSci 2012;4:71-3.
  8. Sultana S., Ahmed I., Islam M.R., Rahman H. Development of Salbutamol Sulphate Sustained Release Pellets Using Acrylic Polymer and Polyvinyl Acetate Polymerand Evaluation of in vitro Release Kinetics. Dhaka Univ. J. Pharm. Sci.2010;9(2):109-118.
  9. Radke RS, Gangane PS, Kawtikwar PS, Rai Sudish. Formulation and Evaluation of Sustained Release System for an Effective Management of Motion Sickness. Research J. Pharm. and Tech. 2008;1(4): 426-429.
  10. Mahajan AN, Pancholi SS. Formulation and evaluation of timed delayed capsule device for chronotherapeutic delivery of terbutaline sulphate. Ars Pharm,2010; 50(4):215-223.
  11. Kadam, V.D., Gattani, S.G. (2009). Formulation and evaluation of a pulsatile drug delivery system using time- and pH-dependant polymers. Pharm Dev Tech. 15:57-63.
  12. Tekade, A.R., Gattani, S.G. (2009). Development and evaluation of pulsatile drug delivery system using novel polymer. Pharm Dev Tech. 14:380-387.
  13. Sinchaipanid N, Chitropas P, Mitrevej A, Influences of layering of theophylline pellets characteristics. Pharm Dev Tech 2004;9:163-170.
  14. Rane, A.B., Gattani, S.G., Kadam, V.D., Tekade, A.R. (2009). Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers. Chem Pharm Bull. 57:1213–7.
  15. Shah VP, Tsong Y, Sathe P. In vitro dissolution profile comparison - statistics and analysis of the similarity factor, f2. Pharm Res, 1998; 15:889-896
  16. Higuchi T. Mechanism of sustained action medication, Theoritical analysis of rate release of solid drugs dispersed in solid matrices, J Pharm Sci., 52: 1145-1149, (1963).
  17. Korsmeyer RW, Gunny R, Peppas NA, Mechanism of solute release from porous hydrophilic polymers, Int J Pharmaceutics, 15: 25-35, (1983).
  18. Devhare LD and Gokhale N. Antioxidant and Antiulcer Property of Different Solvent Extracts of Cassia Tora Linn. Research Journal of Pharmacy and Technology. 2022;15(3);1109-1113.
  19. Tiwari R, Mishra J, Devhare LD and Tiwari G. An updated review on recent developments and applications of fish collagen. Pharma Times. 2023;55(6):28-36
  20. Adimulapu AK, Devhare LD, Anasuya Patil A, Chachda NO, G. Dharmamoorthy. Design and Development of Novel Mini Tablet Cap Technology for the Treatment of Cardiovascular Diseases. International Journal of Drug Delivery Technology. 2023;13(3):801-806
  21. Chawla A, Devhare LD, Dharmamoorthy G, Ritika, Tyagi S. Synthesis and In-vivo Anticancer Evaluation of N-(4-oxo-2- (4-((5-aryl-1,3,4 thiadiazole-2yl) amino) Phenyl thiazolidine-3-yl) Benzamide derivative. International Journal of Pharmaceutical Quality Assurance. 2023;14(3):470-474.
  22. Gnana RPM, Devhare LD, Dharmamoorthy G, Khairnar MV, Prasidha R. Synthesis, Characterisation, Molecular Docking Studies and Biological Evaluation of Novel Benzothiazole Derivatives as EGFR Inhibitors for Anti-breast Cancer Agents. International Journal of Pharmaceutical Quality Assurance. 2023;14(3):475-480.
  23. Sonule M, Devhare LD, Babu MN, Gunjal SD, Varalaxmi S. Microemulgel-based Hydrogel of Diclofenac Sodium using Lipidium sativum as a Gelling Agent. International Journal of Drug Delivery Technology. 2023;13(4):1235-1239.
  24. Shriram BK, Devhare LD, Mehrotra A, Deokar SS, Singh SP. Formulation and Evaluation of Mosquito Repellent Stick. International Journal of Drug Delivery Technology. 2023;13(4):1283-1286.
  25. Choudhary RK, Beeraka S, Sarkar BK, Dharmamoorthy G, Devhare L. Optimizing Verapamil Hydrochloride In-situ Delivery: A Strategic Formulation Approach using Box-Behnken Design for Enhanced Performance and Comprehensive Evaluation of Formulation Parameters. International Journal of Drug Delivery Technology. 2024;14(1):61-70.
  26. Kumar KK, Kiran V, Choudhary RK, Devhare LD, Gunjal SD. Design Development and Characterization of Nicardipine Solid Lipid Nano-Particulars. International Journal of Drug Delivery Technology. 2024;14(1):71-78.
  27. Priya MGR, Prasanth LML, Devhare LD, Yazdan SK, Gunjal S. Synthesis, DNA Binding, Molecular Docking and Anticancer Studies of Copper (II), Nickel (II), and Zinc (II) Complexes of Primaquine-based Ligand. International Journal of Pharmaceutical Quality Assurance. 2024;15(1):69-75.
  28. Uplanchiwar VP, Raut SY, Devhare LD, et al. Pharmacological Assessment of Antiulcer Activity of Gloriosa Superba Linn Tubers In Experimentally Induced Gastric Ulcers. Journal of Medical Pharmaceutical and Allied Science. 2021;10(3);2852-2856.
  29. Tiwari G, Gupta M, Devhare LD, & Tiwari R. Therapeutic and Phytochemical Properties of Thymoquinone Derived from Nigella Sativa. Current Drug Research Reviews. 2024;16(2):145-156.
  30. Chand, G., Devhare, L. D., & Hooda, T. . Diverse Properties of Tinospora Cordifolia (Giloy, Heart Leaved Moonseed) world wild use for immunotherapies; boosting the body’s defence and immune support . Emerging Paradigms for Antibiotic-Resistant Infections: Beyond the Pill. Sringer Nature. 2024;1:471-486
  31. Upreti, P., Devhare, L. D., Abdulmageed, L. H., Kumar, Y. G., Kumar, R., & Dharmamoorthy, G. Combatting Antibiotic Resistance: Leveraging Fecal Microbial transplantation for gut health. Emerging Paradigms for Antibiotic-Resistant Infections: Beyond the Pill. 2024;1:211-232.