International Journal of Drug Delivery Technology
Volume 15, Issue 3

Development and Evaluation of Chitosan Nanoparticle-Loaded Films for Enhanced Bioavailability

Venkata Durga Seshu Priya P1, Ruby S2*, Kumar M2 

1Department of Pharmaceutics, Vinayaka Mission’s College of Pharmacy, VMRF(DU), Salem, Tamil Nadu, India

2Department of Pharmaceutical Chemistry, Vinayaka Mission’s College of Pharmacy, VMRF(DU), Salem, Tamil Nadu, India 

Received: 9th Aug, 2025; Revised: 1st Sep, 2025; Accepted: 9th Sep, 2025; Available Online: 25th Sep, 2025 

ABSTRACT

Memantine-loaded chitosan nanoparticles (MNPs) were created utilizing the ionic gelation technique in order to get over these restrictions. MNP4 was chosen as the optimal formulation for additional characterization because it showed the highest entrapment efficiency (%EE) of 84.73±1.214% among the formulations. According to in vitro tests utilizing a Franz diffusion cell, this improved formulation had a non-Fickian super case II drug release mechanism, first-order release kinetics (r2 = 0.913), and an average particle size of 298.6 nm with a zeta potential (ZP) of +24.5 mV. Using single or mixed polymers, the optimized nanoparticles (MNP4) were then added to thin mucoadhesive buccal films (BFs) via the traditional solvent casting method. The mechanical strength, mucoadhesive qualities, swelling behavior, and in vitro drug release of the resultant buccal films were assessed. MNBF6 was the most effective buccal film among the formulations; it had the highest mucoadhesive strength (7.5±0.22 N) and the largest drug release at the 12-hour mark. Goat buccal mucosa was used for ex vivo permeation tests on this product. The purpose of this study was to compare the improved permeability of memantine from the optimized buccal film loaded with nanoparticles (MNBF6) to a film containing the medication in its plain form (MBF10). The results validate the possibility of using buccal films with Memantine-loaded nanoparticles as a viable substitute delivery method to enhance Memantine bioavailability and therapeutic effectiveness for the management of symptoms associated with Alzheimer's disease.

Keywords: Mucoadhesive drug delivery, Memantine-chitosan nanoparticles, Buccal films, Alzheimer’s disease, Ionic gelation and Non-Fickian drug release.

How to cite this article: Venkata Durga Seshu Priya P, Ruby S, Kumar M. Development and Evaluation of Chitosan Nanoparticle-Loaded Films for Enhanced Bioavailability. International Journal of Drug Delivery Technology. 2025;15(3):1318-25. doi: 10.25258/ijddt.15.3.53

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