International Journal of Drug Delivery Technology
Volume 15, Issue 3

Evaluation Studies of Atenolol NLC-Loaded Transdermal Patches

N Kanagathara1*, L Jeyanthi Rebecca2, S Jaikumar1 

1Department of Pharmacology, Sri Lakshmi Narayana Institute of Medical Sciences, (Affiliated to Bharath Institute of Higher Education and Research, Chennai), Pondicherry-605502, India

2Department of Biotechnology, Bharath Institute of Higher Education and Research, Chennai-600073, India 

Received: 19th Jul, 2025; Revised: 17th Aug, 2025; Accepted: 29th Aug, 2025; Available Online: 25th Sep, 2025 

ABSTRACT

Transdermal patches were analyzed for weight variation to ensure uniform distribution of the drug. The patches were measured for thickness in order to determine their physical dimensions, which plays a crucial role in the consistency of drug release. We evaluated the patch's flexibility and durability by folding them repeatedly, simulating real-world conditions. Analyzing the percentage moisture content of the patches gave insight into their ability to absorb moisture during storage, which was crucial for maintaining their stability. Analysis of drug content ensures consistent dosage delivery by ensuring uniformity and accuracy. Testing the patches' ability to penetrate the skin barrier was conducted using skin membrane models. An evaluation of the patch safety profile was conducted and minimal irritation potential was ensured by testing the patches on the skin. A study of the atenolol release profile from transdermal patches over time was conducted in vitro, providing insight into the patches' potential for sustained release.

Keywords: Atenolol, skin, Evaluation, Transdermal Patches,

How to cite this article: N Kanagathara, L Jeyanthi Rebecca, S Jaikumar. Evaluation Studies of Atenolol NLC-Loaded Transdermal Patches. International Journal of Drug Delivery Technology. 2025;15(3):1326-330. doi: 10.25258/ijddt.15.3.54

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