International Journal of Drug Delivery Technology
Volume 15, Issue 3

A Review on Phytochemical Loaded Nanosponges

D Anusha Reddy, A Vijayalakshmi* 

School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai, Tamil Nadu-600117, India 

Received: 9th May, 2025; Revised: 16th Aug, 2025; Accepted: 3rd Sep, 2025; Available Online: 25th Sep, 2025 

ABSTRACT

Nanomaterials, particularly nanosponges, have shown significant promise in drug delivery and cancer therapy due to their excellent penetration, absorption, biocompatibility, bioavailability, and stability. Nanosponges are crystalline, crosslinked, polymer structures, nansized, porous, and have three-dimensional, hyper-reticulated, structures that are capable of encapsulating an assortment of compounds. Other examples include cyclodextrin based nanosponges, which can be used to create complexes with drugs to increase their solubility and bioavailability as can be seen with its use in delivering lapatinib anticancer drug. Although they are at a very early stage of development and only small molecules are covered, current research is concerned with creativity that innovative designs and synthesis processes have to be made in order to enhance their efficacy and safety. The phytochemical loaded nanosponges are an up and coming development in the field of drug conveyance that shows promising new solubility, controlled discharge, targeting, and upgraded stability of helpful chemicals. The nanosponges are flexible and can be used in a variety of applications, whether it is medical or cosmetic, environmental or food industry. As an example, they can complex with anticancer phytochemicals like curcumin, quercetin and resveratrol where they enhance their therapeutic benefit. Nonetheless, issues like manufacturing complexities, possible toxicity, and regulatory issues need to be surmounted. All in all, phytochemical packed nanosponges offer a new and efficient approach to utilize the therapeutic potential of natural molecules; thus, this is an interesting direction in the development of nanomedicine and cancer treatment.

Keywords: Novel Drug Delivery, Nanosponges, Phytochemicals and Nano Medicine

How to cite this article: D Anusha Reddy, A Vijayalakshmi. A Review on Phytochemical Loaded Nanosponges. International Journal of Drug Delivery Technology. 2025;15(3):1426-32. doi: 10.25258/ijddt.15.3.66

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