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Microemulsions are clear, transparent, thermodynamically stable dispersions of oil and water, stabilized by an interfacial film
of surfactant frequently in combination with a co-surfactant. Recently, there has been a considerable interest for the
microemulsion formulation, for the delivery of hydrophilic as well as lipophilic drug as drug carriers because of its improved
drug solubilization capacity, long shelf life, easy of preparation and improvement of bioavailability. In this present review, we
discuss about the various advantages of microemulsion in pharmaceuticals, along with its preparation, evaluation and research
work carried out on microemulsions.
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Table 1: Research Work carried out on Microemulsions
Drug Name Route Purpose/Result
Flurbiprofen7] Parenteral Increased the solubility
Apormorphine HCL8] Transdermal Increased the permeability
Ketoprofen9] Transdermal Enhancement of permeability
Prilocainne-HCL10] Transdermal Increased the solubility
Estradiol11] Transdermal Improvement in solubilization
Aceclofenac12] Dermatological Increased the solubility
Piroxicam13] Oral Increased the solubility
Diclofenac14] Transdermal Permeability enhancement
Dexamethasone15] Topical Ocular Enhanced the Bioavailability
Chloramphenicol16] Ocular Increased the solubility
Ibuprofen17] Parenteral Increased the solubility
Sumatriptan18] Intranasal Enhanced the Bioavailability
Ibuprofen19] Topical Increasing the solubility
Doxorubicin20] - Increasing the Stability
Itraconazole21] Parenteral For better absorption
Timolol22] Ophthalmic For better absorption
Terbinafine23] Transdermal Permeability enhancement
Fenofibrate24] Self-Micro emulsifying Increasing the solubility
Progesterone25] Dermal Increased the chemical Stability
IJDDT, October-December 2009, Vol.1, Issue 2(39-41) 40
Y. Srinivasa Rao et al. / Microemulsions: A novel drug carrier system
6. Ghosh, P.K. and Murthy, R.S. 2006. Microemulsions: A
potential drug delivery system. Curr. Drug Deliv. 3(2): 167-
7. Park, K.M. and Kim, CK. 1999. Preparation and evaluation of
flurbiprofen-loaded microemulsions for parental delivery.
Int.J.Pharm. 181: 173-179.
8. Peira, E., Scolari, P. and Gasco, M.R. 2001. Transdermal
permeation of apomorphine through hairless mouse skin from
microemulsion. Int. J. Pharm. 226: 47-51.
9. Rhee, Y.S., Choi, J.G., Park, E.S. and Chi, S.C. 2001.
Transdermal delivery of ketoprofen using microemulsions.
Int.J.Pharm. 228: 161-170.
10. Kreilgard, M., Peedersen, E.J. and Jaroszewski, J.W. 2000.
NMR characterization and transdermal drug delivery potential
of microemulsion system. J. Controlled Rel. 69: 421-433.
11. Peltola, S., Saarinen, S.P., Kiesavaara, J. and Urttia, S.T.M.
2003. Microemulsions for topical delivery of estradiol. Int. J.
Pharm. 254: 99-107.
12. Yang, J.H., Kim, Y.I. and Kim, K.M. 2002. Preparation and
evaluation of aceclofenac microemulsions for transdermal
delivery system. Arch.Pharm. Res. 25: 534-540.
13. Andrade, S.M. and Costa, S.M. 2003. Fluorescence quenching
of acridine orange in microemulsions induced by the nonsteroidal anti inflammatory drug piroxicam. Photochem.
Photobiol. Sci. 2: 605-610.
14. Kweon, J.H., Chi, S.C. and Park, E.S. 2004. Transdermal
delivery of diclofenac using microemulsions. Arch. Pharm.
15. Fialho, S.L. and Cunha, D.S. 2004. New vehicle based on a
microemulsion for topical ocular administration of
dexamethasone. Clin. Experiment Ophthalmol. 32:626-632.
16. Lv, F.F., Zheng, L.Q. and Tung, C.H. 2005. Phase behavior of
the microemulsions and stability of the chloramphenicol in
microemulsion based ocular drug delivery system. Int. J. Pharm.
17. Zhao, X., Chen, D., Gao, P., Ding, P. and Li, K. 2005.
Synthesis of ibuprofen eugenol ester and its microemulsion
formulation for parental delivery. Chem. Pharm. Bull. 53:1246-
18. Vyas, T.K., Babbar, A.K., Sharma, R.K., Singh, S. and Misra,
A. 2006. Preliminary brain targeting studies on intranasal
mucoadhesive microemulsions of sumatriptan. AAPS Pharm.
Sci. Tech. 20: E8.
19. Chen, H., Chang, X., Du, D., Li, J., Xu, H. and Yang, X. 2006.
Microemulsion based hydrogel formulation of ibuprofen for
topical delivery. Int. J. Pharm. 315: 52-58.
20. Formariz, T.P., Sarmento, V.H., Silva, J.A.A., Scarpa, M.V.,
Santilli, C.V. and Oliveira, A.G. 2006, Doxorubicin
biocompatible o/w emulsion stabilized by mixed surfactant
containing soya phosphotidyl choline. Colloids Surf. B.
21. Rhee, Y.S., Park, C.W., Nam, T.Y., Shin, Y.S., Chi, S.C. and
Park, E.S. 2007. Formulation of parental microemulsion
containing itraconazole. Arch Pharm. Res. 30: 114-123.
22. Li, C.C., Abrahamson, M., Kapoor, Y. and Chauhan, A. 2007.
Timolol transport from microemulsions trapped in HEMA gels.
J. Colloid Interface Sci. 315: 297-306.
23. Baboota, S., AL-Azaki, A., Kohli, K., Ali, J., Dixit, N. and
Shakeel, F. 2007. Development and evaluation of a
microemulsion formulation for transdermal delivery of
terbinafine. PDA J. Pharm. Sci. Technol. 61: 276-285.
24. Patel, A.R. and Vavia, P.R. 2007. Preparation and in vivo
evaluation of SMEDDS containing fenofibrate. AAPS J. 9:
25. Biruss, B. and Valenta, C. 2008. The advantage of polymer
addition to a non-ionic oil in water microemulsion for the
develop delivery of progesterone. Int.J.Pharm. 349: 269-273.