Studying the Release Characteristics of Naproxen Sustained Release Matrix Tablet Using Natural Polyelectrolytes

Zahraa Oleiwi Hamzah, Wedad k. Ali


Aim: This work involves studying the release characteristics of naproxen sustained release matrix tablet using natural polyelectrolytes and studying some variables affecting the formulation such as the effects of (PEC formation, polymer-polymer ratio, anionic polymer type, molecular weight of CS, type and amount of diluent) on the release rate of naproxen.
Methods: Sixteen formula were prepared using direct compression with 500 mg total tablet weight. The release properties of naproxen sustained release matrix tablets were investigated using USP dissolution apparatus I (basket). FT-IR spectra of the complexes were studied to indicate the interactions between polyions.
Results: The results showed that the release rate of naproxen was decreased in the formulas that contains PEC comparing to the formulas with single polymer. The formula containing CSh: SA prepared in the ratio of (3:1) showed the slowest release rate (68.17% of naproxen in 7 hr) and extended the release up to 15 hr. It was seen that the formula containing CSh: XG in 3:1 ratio formed the strongest PEC and the release rate extended up to 20 hr. On the other hand changing the molecular weight of CS from high to low and the type of diluent from lactose monohydrate to MCC showed a non-significant increase in the release rate.
Conclusion: Polyelectrolyte complex prepared from cationic polymer CS and anionic polymer of SA, XG and CG physical mixtures was successfully formed. Formula 13 formed the strongest PEC with a ratio of CS: XG equal to (3:1) which extended the release up to 20 hr.


chitosan, matrix tablet, naproxen, polyelectrolytes, sustained, xanthan

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