Practical Approaches for Taste Masking of Bitter Drug: A Review

Gupta K., Madaan S., Dalal M., Kumar A., Mishra N., Singh K., Verma S.


Taste is most important organoleptic aspects about the acceptance of oral drugs. Bitter and unpalatable taste is a major
problem of certain drugs in formulations. In market, there are numbers of pharmaceutical preparations available in which actives
are bitter in taste. The improved palatability in these products has prompted the development of numerous formulations, which
improved performance and acceptability. The bitterness of preparation also leads to patient incompliance. So masking of bitterness
becomes essential and done by masking the bitter taste of drugs by either decreasing its oral solubility on ingestion or decreasing
the amount of drug particles exposed to taste buds thereby reducing the perception of bitter taste. Methods commonly used for
taste masking involves various physical and chemical method that prevent the interaction of taste bud with drugs and are based on
coatings, solid dispersion system and ion exchange resin, entrapment method and masking of taste buds etc. Taste masking of
bitter drugs become necessity in case of oral administration and selection of technology depends upon the bitterness of drugs and
their compatibility with taste masking agents that does not affect the bioavailability of drug


Taste buds, Flavors, Cyclodextrins, Eudragit, E-tongue

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