Development of Solid Lipid Nanoparticles of Lamivudine for Brain Targeting

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Pravin Patil
Anil K Sharma
Subhash C Dadarwal
Vijay K Sharma
U. S. Baghel

Abstract

The objective of present investigation was to enhance brain penetration of Lamivudine, one of the most widely used drugs for
the treatment of AIDS. This was achieved through incorporating the drug into solid lipid nanoparticles (SLN) prepared by
using emulsion solvent diffusion technique. The formulations were characterized for surface morphology, size and size
distribution, percent drug entrapment and drug release. The optimum rotation speed, resulting into better drug entrapment and
percent yield, was in the range of 1000-1250 r/min. In vitro cumulative % drug release from optimized SLN formulation
was found 40-50 % in PBS (pH-7.4) and SGF (pH-1.2) respectively for 10 h. After 24 h more than 65 % of the drug
was released from all formulations in both mediums meeting the requirement for drug delivery for prolong period of time.

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Author Biography

Pravin Patil, Formulation and Development Laboratory, Indoco Remedies Limited, Mumbai, INDIA