Distribution of fimH Gene in Local Isolates of Adhesive Uropathogenic Escherichia coli

Omar Abdulkareem Ali, Ruqayah Qubtan Taha

Abstract


Adhesion is an influential step for bacterial vigor in clinical micro-environments, type 1 fimbriae are essential virulence factors help uropathogenic E. coli in invasion and colonization of uroepithelial cells, the first step of UTIs and biofilm formation. Type 1 fimbriae of E. coli contain FimH protein at the tip encoding via fimH gene cluster, this study was conducted for determination the fimH gene distribution in uro-pathogenic E. coli isolated from UTIs patients.
The results of adhesion assay show that (83.6%) of uropathogenic E. coli were high adherent isolates. While the results of E. coli fimH gene amplification prove that, of all E. coli isolates, the fimH gene was found in (87.1%), while among high adherent isolates it was found in (92.6%), and that Shows the function of type 1 fimbriae in the colonization and infection of urinary tracts in addition to other adhesions virulence agents of uropathogenic E. coli.

Keywords


fimH gene; Type 1 fimbriae; Uropathogenic E. coli; Adhesion

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DOI: https://doi.org/10.25258/ijddt.v9i3.9

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