Potential activity of crude alkaloids against Echinococcus granulosus in adult albino male rats

Abeer A. Ali, Ahmed Hamad Saleh

Abstract


Study was designed to show the activity of crude alkaloids against toxicity of E. granulosus. 20 adult albino male rats were used in present study and divided randomly to following groups (each group consist 5 rats); control group received ad libidium, posistive group injected with 2,5 X 103 of E. granulosus protoscolices third group injected with protoscolices and treated with 0.25 mg/ml crude alkaloids, fourth group injected with protoscolices and treated with 0.25 mg/ml crude alkaloids. The results show high Scavenging activity of crude alkaloids extracts reach to 88.6%. Otherwise, The results show high significant increased (p less than 0.05) in levels of Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP) in group injected with protoscolices compared with control group. Oxidative stress factor in group injected with protoscolices show significant increased (p less than 0.05) in levels of MDA (malonedialdehyied) and significant decreased (p less than 0.05) in levels of glutathione (GSH) and catalase compared with control group. While, after used crude alkaloids with E. granulosus, the results showed non-significant changes (p less than 0.05) in liver functions and MDA, GSH and catalase also showed non-significant changes (p less than 0.05) compared with control group. It was concluded that crude alkaloids has been potential role against toxicity of Echinococcus granulosus in male rats.

Keywords


crude alkaloids; Echinococcus granulosus; liver function; MDA (malonedialdehyied); glutathione (GSH); catalase.

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DOI: https://doi.org/10.25258/ijddt.v9i3.11

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