The Phosphatase And Tensin Homolog-Gene (PTEN-Gene) Expression Level is a Novel Indicator for Poor Prognosis in Invasive Ductal Carcinoma

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Adel Mosa AL-Rekabi
Shoroq Mohammed AL-Temimi

Abstract

The objective of the present work was to formulate and evaluate floating microspheres containing Roxatidine acetate HCl prepared by emulsion solvent diffusion technique. To achieve extended retention in the upper gastrointestinal tract (GIT), this may result in enhanced absorption and thereby improved bioavailability. Roxatidine acetate HCl is a competitive H2 receptor antagonist used to treat gastric ulcers. Floating microspheres systems have a density less than gastric fluids, and so these systems remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period. Floating microspheres were prepared by using hydroxy propyl methyl cellulose (HPMC K4M and HPMC K15M) and ethyl cellulose. The microspheres were evaluated for parameters like particle size, entrapment efficiency, shape and surface morphology, drug content, in-vitro drug release study and drug release kinetic study. The floating microspheres were found to be spherical, and the FTIR study confirmed the drug-polymer compatibility. All floating microspheres formulations showed good flow properties, and buoyancy was found to be 71–87%. Among all formulations, F2 showed an appropriate balance between buoyancy and drug release rate (90% in 12 hour); hence it is considered as the best formulation. The data obtained in this study thus suggests that the floating microspheres of roxatidine acetate HCl are promising for sustained drug delivery, which can be used for reducing dosing frequency.


How to cite this article: AL-Temimi, S.M. and AL-Rekabi, A.M. (2019). The Pten-Gene Expression Level is a Novel Indicator For Poor Prognosis in Invasive Ductal Carcinoma. International Journal of Drug Delivery Technology, 9(4): 538-543.

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Research Article