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Liquid electrodes of Pyrazinamide (PZD) imprinted polymer were synthesis based on precipitation polymerization mechanism. The molecularly imprinted (MIP) and non-imprinted (NIP) polymers were synthesized using PZD as a template. By 1-Vinylimidazole (VIZ) and methyl methacrylate (MMA) as monomers, trimethylolpropane trimethacrylate(TPT) cross-linkers and benzoyl peroxide (BPO) as an initiator. The molecularly imprinted membranes were synthesis using Dibutyl Sebacate (DBS), Dibutyl phthalate (DBPH), Dioctyl phthalate(DOPH), and Nitrobenzene (NO) as plasticizers in PVC matrix. The slopes and limit of detection of liquid electrodes obtained from the calibration curves ranged from (-27.86– 29.96) mV/decade and 1.8 x 10-5 – 6.0 x 10-6 M, respectively, and the response time was about 60 seconds. The Liquid electrodes were filled with 10-1 M standard solution of the drug and observed stable response for a pH ranged from 2.0 to 11.0 and with good selectivity for over several species. The fresh electrodes of synthesis were effectively used in the pharmaceutical sample to determine PZD without any time-consuming pretreatment measures.
How to cite this article: Mudhi, M.A., Al-Bayati, Y.K. and Al-Samarrai, K.F. (2019). Synthesis New Liquid Electrodes For Determination Pyrazinamide Based On A Molecularly Imprinted Polymer. International Journal of Drug Delivery Technology, 9(4): 645-650.
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