Synthesis, Characterization and Study Biological Activity of Five and Seven Heterocyclic Compounds.

Fiadh A. Neshan, Muna S. Al-Rawi, Jumbad H. Tomma

Abstract


of 2-(1-(naphthalen-2-yl) ethylidene) hydrazine-1-carbothioamide [I] with ethyl α-chloroacetate in the presence of fused CH3COONa. The new 2-thioxo-imidazlidin-4-one derivatives containing heterocyclic unit, five, and seven-member ring\ were successfully formed, such as imidazoline-4-one, tetrazole, thiazolidin-4-one, and 1,3-oxazepinerings. The synthesized derivatives were characterized by their FTIR,1H-NMR, mass spectra, and CHN-S. Furthermore, the synthesized compounds have been screened for their antibacterial activity against E.col (G-), Staph. Aureus (G+), and Bacillus cereus(G+), and compared to Ampicillin, Amoxicillin, and Lincomycin as antibiotic standards.

Keywords


2-thioxo-imidazolidine-4-ones, 1,3-oxazepine, Antibacterial activities, Cycloaddition reaction, Imidazolidin-4- one, Tetrazole, Thiazolidin-4-one.

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DOI: https://doi.org/10.25258/ijddt.v9i4.12

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