Synthesis and Biological Studies of Some Diazo Dyes As New Drugs

Hanan M Ali, Sanaa Qassem Badr, Asawer Salim Temma

Abstract


The novel azo dye (1) and diazo dye (2) was synthesized from two different drugs (paracetamol and cefpodoxime proxetil), followed by the purification and characterization of each. Then, the antimicrobial activities of (1) and (2) were screened in vitro towered Klebsiella spp., Aspergillus terreus and Candida glabrata infections by using different concentrations (0.008, 0.016 and 0.2 mg/mL) from each. Azo dye (1) is given high antimicrobial activity against gram-negative bacteria Klebsiella spp., good activity against Candida glabrata, and no activity against Aspergillus terreus. These activities were seemed to be better than that received by the diazo dye (2) using the same concentrations. The results were also showed that the synthetic dyes provided a non-toxic effect and didn’t show any hemolysis effect in the cells. Further, the results were indicated that each synthetic dye was treated the dull infection with Candida glabrata and Klebsiella spp. with good results, but the results of (1) still better than (2). Due to recommend these dyes as new drugs for disseminated infections with the two microorganisms.

Keywords


Antimicrobial activity, Aspergillus terreus, Azo dyes, Candida glabrata, Infection, Klebsiella spp.

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DOI: https://doi.org/10.25258/ijddt.v9i4.16

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