Hepatitis C and IL-6 with 174G/C Gene Polymorphism in β-Thalassemia

Aqeel A Alsadawi, Al-Karrar Kais Abdul Jaleel duabel, Haider A Alnaji

Abstract


Polymorphisms have been shown to affect the progression of disease in patients with Iraqi thalassemia in the 174 G\C area of IL-6. The objective of this research was, therefore, to determine the connection of IL-6 gene polymorphisms and thalassemia severity in Iraqi patients. Case-control research of 60 patients diagnosed with β-TM at the thalassemia center in AL-Zahra hospital in AL-Najaf City, Iraq, with a group of 40 healthy patients, was used as control; the patients (26 males and 34 females) were 3–49 years of era. Blood samples were gathered and controlled from all patients. Blood used to extract DNA to detect IL-6 G\C polymorphism using SSP-PCR. The outcome showed that the male age range (56.6%) was higher than the woman (42.6%), and the age range (10-19) was higher than the other. The outcome shows that GG genotype and G allele in thalassemia patients are a risk factor of severity, whereas CC genotype and C allele are a protective factor of severity. Conclusion: The polymorphism in IL-6 at a place (174 G\C) is associated with thalassemia pathogenesis in the GG genotype and IL-6 considers the seriousness of thalassemia as a predictive factor

Keywords


HCV, IL-6 polymorphism, Splenectomies, Thalassemia.

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DOI: https://doi.org/10.25258/ijddt.v9i4.17

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