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Nanoemulsion considers a novel drug delivery system that permits controlled or sustained drug release. It is a dispersion consisting of a surfactant, oil, and clear aqueous phase, kinetically, or thermodynamically stable with droplet diameter 10-100nm. Nanoemulsion applied to increase the solubility and bioavailability of lipophilic drugs; they have many advantages for drug delivery. There are many methods for Nanoemulsion preparation like High –energy emulsification method, Spontaneous Nanoemulsion, Phase inversion temperature (PIT). It applied for many routes of delivery, thus providing a promising effect for many fields such as cosmetics, therapeutic, and biotechnology.
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