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A new series of Imidazo[2,1-b]benzothiazole derivatives were designed, synthesized in good yields, and biologically evaluated in this contribution, by following a known procedure in literature, a 2-(p-bromo phenyl and p-biphenyl) Imidazo[2,1-b]benzothiazole derivatives were synthesized. These derivatives were subjected to Vilsmeier-Haack conditions to form the 3-substituted carbaldehydes. These aldehydes were converted to azlactone derivatives by using hippuric acid; then, azlactone were turned to imidazolones by reacting with different amines. Additionally, aldehydes were also reacted with thiosemicarbazide to afford new thiosemicarbazones, which they are cyclized to triazole and thiadiazol acetamide derivatives by using HCl and acetic anhydride subsequently. These new compounds were tested against different microbes and showed moderate to high activity to suppress them.
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