A New Approach for Polymer-Free Coating with Paclitaxel Microparticles on Fully-Bioabsorbable Poly(l-Lactic Acid) Stent and Studies of Drug Release Behavior

Hirokazu Yamada, Mitsuhiko Kinoshita, Shinichi Yagi, Chisa Matsubara, Keiji Igaki, Hideki Yamane


A first clinically-used, fully-bioabsorbable poly(L-lactic acid) (PLLA) stent was coated with microcrystals of paclitaxel (PTX),
antiproliferative agent through seeding and/or crystal growing technique to investigate the drug properties on the stent surface and drug
release behavior from the stent. PTX particles subject to only seeding process was peeled off after stent compression, while less PTX
was coated on the stent subject to only crystal growth without seeding. PLLA stent with both processes could stably maintain an increased
amount of PTX on its surface. The maximum amount of initial release (10 μg/cm2) was found in the sample only with seeding, which
decreased to 3 μg/cm2 or below after one week. Also in the PLLA stent only with crystal growth, release amount decreased after one
week. In the PLLA stent with seeding and crystal growth, formation of needle-like PTX crystals on the surface resulted in decreased
initial release and lower solubility after hydration in phosphate buffered solution compared to other types of stent with different procedures.
It is suggested that both seeding and crystal growth are required for stable application of PTX on fully-bioabsorbable PLLA stent and
needle-like crystals containing water have lower aqueous solubility resulting in decreased PTX release.


Polymer-free; Bioabsorbable; Stent; Paclitaxel; Microparticle; Drug release

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DOI: https://doi.org/10.25258/ijddt.v5i2.8871


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