Anticancer Activity of Zingiber officinale Bound Dendrimer - An Invitro Analysis

Indhumathy M., Bavanilathamuthiah , Carlin Malar

Abstract


Zingiber officinale (sukku), one of the naturally occurring medicinal plants, has been consumed worldwide as a spice and
flavoring agent from the ancient time. Zingiber officinale bears an enormous number of pharmacological activities
including Neuro-protective activity and anticancer activity facilitating the extent of further research for finding out less
toxic and more potent drugs for the better treatment of those diseases. Dendrimers are nanostructured macromolecules,
immensely branched; three dimensional displays an essential role in the emerging field of Nanomedicine.Dendrimers have
potential application in gene and drug delivery system. We examine the interaction of DNZ’s (zingiber officinale bound
Dendrimer) by UV – visible spectroscopy and Fourier transform infrared spectroscopy (FTIR). The anticancer activity
of DNZ’s was estimated against HaCaT and HEp 2 compared with Dendrimer and zingiber officinale. The IC50 values of
DNZ’s were 63 µg/ml for normal cell line (HaCaT) and 32 μg/ml for cancer cell line (HEp 2). This shows that DNZ’s has
high anticancer activity compared to naked Dendrimers and zingiber officinale. The results indicate that functionalization
of zingiber officinale with Dendrimer and successive solubilization could play an important role in the enhancement of
anticancer activity.

Keywords


Dendrimer, zingiber officinale, anticancer activity, HaCaT, HEp 2.

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DOI: https://doi.org/10.25258/ijddt.v5i3.8873

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