Biocompatibility of Silver Nano Bio-conjugates from Vitis vinifera Seeds and its Major Component Resveratrol

R. Preethi, P. Padma

Abstract


The study focused on the green synthesis of silver nanobioconjugates (AgNPs) from phenolic-rich fruit source, Vitis
vinifera seed extract and its major component phenolic, resveratrol respectively. Sunlight exposure for 20 minutes was the
method of choice for the synthesis of AgNPs of the extract as well as the phenolic, resveratrol. The synthesized
nanobioconjugates were characterized using UV-Visible spectroscopy, Transmission electron microscopy (TEM), Energy
dispersive X-ray analysis (EDAX), X-ray diffraction (XRD), Polydispersity index, Zeta potential and Fourier transform
infrared spectroscopy (FTIR). The reduction of silver ions was confirmed by UV-visible spectroscopy with peaks at 440nm
for both nanobioconjugates synthesized from seed extract and compound. The nanobioconjugates showed the spherical in
shape with 14-35nm in size and crystalline in nature. The conjugates are well dispersed with 0.301 and 0.287 polydispersity
index and the zeta potential range at -13.6 and -14.3mV for stability. The FTRI data proved that the components in grape
seeds act as good reductants and stabilizers for the silver nanobioconjugate synthesis. All the synthesized
nanobioconjugates exhibited steady and sustained release of the medicinal components conjugated, proving their
druggability, and were biocompatible with human cells, demonstrating their safety. The findings of the study validate the
anticancer properties of silver nanobioconjugates of Vitis vinifera and its active component resveratrol.

Keywords


Vitis vinifera, resveratrol, druggability, biocompatibility.

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DOI: https://doi.org/10.25258/ijddt.v6i3.8896

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