Potential Activity of Crude Alkaloids against Echinococcus Granulosus in Adult Albino Male Rats

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Abeer A Ali
Ahmed H Saleh

Abstract

The study was designed to show the activity of crude alkaloids against the toxicity of E. granulosus. In this study, a total of 20 adult albino male rats were used and divided randomly to following groups (each group consist 5 rats); control group received ad libidium, positive group injected with 2,5 X 103 of E. granulosus protoscolices third group injected with protoscolices and treated with 0.25 mg/ml crude alkaloids, fourth group injected with protoscolices and treated with 0.25 mg/mL crude alkaloids. The results show high Scavenging activity of crude alkaloids extracts reaches 88.6%. Otherwise, The results show a highly significant increased (plessthan 0.05) in levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) in the group injected with protoscolices compared with the control group. Oxidative stress factors in the group injected with protoscolices show significant increased (plessthan 0.05) in levels of malonedialdehyied (MDA) and significantly decreased (plessthan 0.05) in levels of glutathione (GSH) and catalase compared with control group. While, after used crude alkaloids with E. granulosus, the results showed non-significant changes (plessthan 0.05) in liver functions and MDA, GSH and catalase also showed non-significant changes (plessthan 0.05) compared with the control group. It was concluded that crude alkaloids has been a potential role against the toxicity of Echinococcus granulosus in male rats.

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How to Cite
1.
Ali A, Saleh A. Potential Activity of Crude Alkaloids against Echinococcus Granulosus in Adult Albino Male Rats. Int J. Drug and Delivery [Internet]. 21Jan.2019 [cited 2Jul.2020];9(03):9-2. Available from: http://ijddt.com/index.php/IJDDT/article/view/72
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Research Article