A Review on Emerging Floating Drug Delivery System

Christe Mary M, Sasikumar Swamiappan

Abstract


Presently, various approaches have been exploited in the prolongation of gastric residence time which includes floating
drug delivery system (FDDS), swelling and expanding systems, bio-adhesive systems, modified shape systems and high
density systems. Among various methods, floating drug delivery system is considered to be a predominant method. Gastric
emptying of dosage forms is an extremely varying process and ability to extend and control the emptying time is a valuable
resource for the dosage forms. This FDDS is having the ability to provides a solution for this purpose. The FDDS is a bulk
density system lower than the gastric fluid, so that the rest will float on the stomach contents for a prolonged period of time
and allowing the drug to release slowly at a desired rate from the system and intensifies the bio-availability of the drug
having narrow absorption window. The main intension of writing this review on floating drug delivery system is to study
the mechanism of flotation to acheive the gastric retention and to discuss briefly about the background of FDDS, advantages
and disadvantages, application of FDDS and factors affecting the gastric retension time.

Keywords


Floating drug delivery system (FDDS), Oral route of drug delivery, Classification of FDDS, Mechanism of FDDS, Factors affecting FDDS, Sustained release.

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DOI: https://doi.org/10.25258/ijddt.v6i4.8901

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