Understanding the Impact of Polymer Ratio and its Concentration on Omeprazole Release from Matrix Tablets: Response Optimization Study

Tiwari R., Tiwari G., Wal P., Wal A., Maurya P.

Abstract


In present study, matrix tablets of Omeprazole (OPZ) were formulated by wet granulation technique using a combination
of hydroxyl propyl methyl cellulose (HPMC K15M) and ethyl cellulose (EC) in varying ratios and the effect of polymer
ratio as well as their concentration on drug release profile was investigated. Response surface methodology (RSM) was
conducted to optimize matrix tablets. Compressed tablets were evaluated for hardness, friability, weight variation, drug
content and in vitro dissolution studies. The dissolution study was performed in pH1.2 for the first 2 h and in phosphate
buffer (pH 7.4) for another 5 h. The optimized formulation was compared with other formulations using similarity (ƒ2)
and dissimilarity factor (ƒ1) test. The results of RSM indicated that both X1 (the blending ratio of HPMC K15M K15M
and Carbopol 934P 934P) and X2 (polymer blend concentration)have significant effect on in-vitro drug release profile.
Hardness, friability, weight variation and drug content were found to be in desired range. Among different formulations,
matrix tablets prepared by HPMC K15M and Carbopol 934P 934P (7:3) with 15% polymer blend concentration
displayed 98.85% OPZ release in 7 hr. and release kinetic was higuchi (r
2= 0.9884). Similarity (f2) and dissimilarity (f1)
factors demonstrated that the in vitro profiles were not similar. Finally, it was concluded that release rate of OPZ
decreased proportionally with increasing polymer ratio (HPMC K15M: Carbopol 934P 934P) and decreasing polymer
blend concentration.

Keywords


Omeprazole, matrix tablets, Response surface methodology, in vitro release.

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DOI: https://doi.org/10.25258/ijddt.v7i1.8912

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