Improved Solubility and Dissolution Rate of Ketoprofen by Beta Cyclodextrin Ternary Complexes Incorporating Hydrophilic Polymers

Mohammed Jafar, Sadath Ali, Hassan Ghonaim


The aim of the presentstudy wasto improve the aqueous solubility and dissolution rate of a BCS Class-IIdrug,ketoprofen
by β-cyclodextrin ternary complexes incorporating hydrophilic polymers polyethylene glycol 6000 (PEG6000) and
polyvinyl pyrrolidone (PVP). Initially,ketoprofen (KPF)binary complexes with β-Cyclodextrin (βCD)wereformulated by
physical mixing,co-grinding, and solvent evaporation methods which was followed by ternary complex formulation of
selected KPF-βCD binary complex incorporatingPEG6000 and PVP.The solvent evaporation method was used in the
formulation of ternary complexesof ketoprofen, sincein the beginning of this study, it was proved to be the best
methodcomparatively in yielding promising binary complexes of ketoprofen.Ketoprofen formed 1:1 M stoichiometric
binary and ternary inclusion complexes as demonstrated by the AL-type of phase solubility graph. An increase in the
stability constant value (Kc) of KPF- βCD complex in the presence of PEG6000 and PVP conceded higher complexation
competency. FTIR and SEM studies evidenced the perfect ternary inclusion complex formation. Ternary complexes
showed improved drug dissolution compared with Ketoprofenalone and KPF-βCD binary complex. The ternary complex
containg 1:1:2 molar ratio of KPF:βCD:PEG6000exhibited 94.24% drug dissolution in 2 hours, which was significantly
high in relation to ternary complexes containg PVPand it was found to follow first order release mechanism. Complex
studied for stabilityshowed no significant change in physical appearance, drug content and drug dissolution characteristic
indicating high stability.


Ketoprofen; Inclusion complex; Hydrophilic polymers; Stability.

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