Acyclovir Loaded Solid Lipid Nanoparticle Based Cream: A Novel Drug Delivery System

EL- Assal I. A., Retnowati .


Objective of the present investigation was enthused by the possibility to develop solid lipid nanoparticles (SLNs) of
hydrophilic drug acyclovir. Also study vitro and vivo drug delivery. Methods: Drug loaded SLNs (ACV-SLNs) were
prepared by high pressure homogenization of aqueous surfactant solutions containing the drug-loaded lipids in the melted
or in the solid state with formula optimization study (Different lipid concentration, drug loaded, homogenization / stirring
speed and compritol 888ATO: drug ratio). ACV - SLN incorporated in cream base. The pH was evaluated and rheological
study. Drug release was evaluated and compared with simple cream- drug, ACV – SLN with compritol 888ATO and
marketed cream. The potential of SLN as the carrier for dermal delivery was studied. Results: Particle size analysis of
SLNs prove small, smooth, spherical shape particle ranged from 150 to 200 nm for unloaded and from 330 to 444 nm for
ACV loaded particles. The EE% for optimal formula is 72% with suitable pH for skin application. Rheological behavior is
shear thinning and thixotropic. Release study proved controlled drug release for SLNs especially in formula containing
compritol88 ATO. Stability study emphasized an insignificant change in SLNs properties over 6 month. In-vivo study
showed significantly higher accumulation of ACV in stratum corneum, dermal layer, and receptor compartment compared
with blank skin. Conclusion: AVC-loaded SLNs might be beneficial in controlling drug release, stable and improving
dermal delivery of antiviral agent(s).


Solid lipid nanoparticles (SLNs), Acyclovir, Release study, vivo trails.

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