International Journal of Drug Delivery Technology
Volume 14, Issue 1

Formulation and Optimization of Valganciclovir-loaded Nanosponges

Alka Singh*, Chetan S Chauhan

Bhupal Nobles’ Institute of Pharmaceutical Sciences, Bhupal Nobles’ University, Udaipur, Rajasthan, India. 

Received: 03rd November, 2023; Revised: 16th December, 2023; Accepted: 18th February, 2024; Available Online: 25th March, 2024

ABSTRACT

The objective of our study was to form a novel method of delivering drugs that would improve the effectiveness of valganciclovir, an antiviral medication used to treat cytomegalovirus (CMV) infection in individuals with weakened immune systems. The drug’s induction dosage has limited penetration and requires very high doses. The nanosponges were synthesized using the emulsion solvent diffusion method, employing a 32 full factorial design to determine the combined impact of 2 independent variables: Quantity of ethyl cellulose and stirring speed. The dependent variables assessed were zeta potential, polydispersity index (PDI), and entrapment efficiency. Improved formulation exhibited an entrapment efficiency of 83.61%, a zeta potential. of -17.6 mV, and a PDI of 0.51. The improved formulation exhibited a continuous and controlled release of the medication. The produced nanosponges were characterized using fourier transform infrared (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM).

Keywords: Nanosponges, Valganciclovir, 32 full factorial design, Emulsion solvent diffusion. International Journal of Drug Delivery Technology (2024); DOI: 10.25258/ijddt.14.1.01

How to cite this article: Singh A, Chauhan CS. Formulation and Optimization of Valganciclovir-loaded Nanosponges. International Journal of Drug Delivery Technology. 2024;14(1):1-8.

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